Microgravimetric immunosensors

There are mainly three types of transducers used in immunosensors electrochemical, optical, and microgravimetric transducers. The immunosensors may operate either as direct immunosensors or as indirect ones. For direct immunosensors, the transducers directly detect the physical or chemical effects resulting from the immunocomplex formation at the interfaces, with no additional labels used. The direct immunosensors detect the analytes in real time. For indirect immunosensors, one or multiple labeled bio-reagents are commonly used during the detection processes, and the transducers should detect the signals from the labels. These indirect detections used to need several washing and separation steps and are sometimes called immunoassays. Compared with the direct immunosensors, the indirect immunosensors may have higher sensitivity and better ability to defend interference from non-specific adsorption. 

Moreover, there is another important type of microgravimetric immunosensor which is based on the immunological agglutination events. The agglutination immunoreaction... 

Owen, T. W. A1 Kaysi, R. O. Bardeen, C. J. Cheng, Q., Microgravimetric immunosensor for direct detection of aerosolized influenza A vims particles, Sens. Actuators B Chem. 2007, 126, 691 699... 

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Blonder, R., Levi, S., Tao, G., Ben-Dov, L, and Willnet I. Development of anaperometric and microgravimetric immunosensors and reversible immunosensors using antigen and photoisomerizable antigen monolayer electrodes. J. Am. Chem. Soc. 1997, 119, 10467-10478. 

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