Immunological reserve

TABLE 5.1-4 Immunological Reserve Demonstrated by Induction of Latent Virus Recrudescence Using Monoclonal Antibodies to NK, CD4, or CDS Cells Either Singly or in Combinations (Polic et al., 1998)... 

Initially, the main concern with commercial PCP products was the contamination with PCDDs (albeit not TCDD) as by-products from the manufacturing process, and many of the envirotoxic effects originally attributed to PCP have been shown to be effects of the dioxins. Toxic actions directly related to PCP are uncoupling of oxidative phosphorylation resulting in increased metabolism and the breakdown of energy reserves, immunological effects, liver and kidney damage and reproductive disturbances (National Research Council, 1986 Eisler, 1989). Today the use of PCP is rather restricted, but in areas where the preparations are still in extensive use, PCP poses a threat to aquatic environments in particular. 

Dennis J. Stuehr (207) Department of Immunology, The Cleveland Clinic, Cleveland, Ohio 44195 and Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio 44106... 

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