Immunoglobulins genetic variants

The proteins of milk fall into several classes of polypeptide chains. These have been delineated most completely in bovine milk, and a system of nonmenclature has been developed for them (Chapter 3 Eigel et al. 1984). One group, called caseins, consists of four kinds of polypeptides asr, as2-. and 3-, and k- with some genetic variants, post translational modifications, and products of proteolysis. Almost all of the caseins are associated with calcium and phosphate in micelles 20-300 fim in diameter (see Chapter 9). The other milk proteins, called whey proteins, are a diverse group including /3-lactoglobulin, a-lactalbumin, blood serum albumin, and immunoglobulins (Chapter 3). Almost all... 

Natvig, J. B., and Kunkel, H. G. (1973). Human Immunoglobulin Classes, Subclasses, Genetic Variants, and Idiotypes. Adv Immunol 16 1. 

Table 3.1 lists the approximate molecular weight and carbohydrate content of H chains of the major human immunoglobulin classes. Exclusive of carbohydrate content the molecular weights of the y and a chains are approximately equal the /j., 8, and e chains are somewhat larger. The H and L chain that constitute the basic subunit of each class are linked by an interchain disulfide bond and by noncovalent interactions. [In the Agmfl) genetic variant of human IgA2, the L chains are bound to H chains only through noncovalent interactions.] The general locations of interchain disulfide bonds in the various classes are indicated by the sketches in Table 3.1. Each H chain is joined to an L chain through a...

Hill MR, Cookson WO. A new variant of the beta subunit of the high-affinity receptor for immunoglobulin E (Fc epsilon Rl-beta E237G) associations with measures of atopy and bronchial hyper-responsiveness. Hum Mol Genet 1996 5(7) 959-962. 

Shirakawa T, Li A, Dubowitz M, Dekker JW, Shaw AE, Faux JA, Ra C, Cookson WO, Hopkin JM. Association between atopy and variants of the beta subunit of the high-affinity immunoglobulin E receptor. Nat Genet 1994 7(2) 125-129. 

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