Immunoglobulins gene transcription

Restricted cell-type specificity of immunoglobulin gene transcription... 

Queen, C., and Baltimore, D., 1983, Immunoglobulin gene transcription is activated by downstream sequence elements. Cell 33 741-748. 

The first signal is supplied by the activity of cytokines, IL-4/IL-13 these molecules are responsible for determining isotype specificity, i.e., immunoglobulin gene transcription at a specific region of the Ig locus in B cells (185,186). The... 

Kelley, D.E., Wiedemann, L.M., Pittet, A.-C., Strauss, S., Nelson, K.J., Davis, J., Van Ness, B., Perry, R.P. (1985). Nonproductive kappa immunoglobulin genes recombinational abnormalities and other lesions affecting transcription, RNA processing, turnover, and translation. Mol. Cell. Biol. 5,1660-1675. 

Peters, A. Storb, U. (1996). Somatic hypermutation of immunoglobulin genes is linked to transcription initiation. Immunity 4, 57-65. 

Schlissel, M.S. Baltimore, D. (1989). Activation of immunoglobulin kappa gene rearrangement correlates with induction of germline kappa gene transcription. Cell 58,1001-1007. 

Figure 3.4 A possible scheme for IgE transcription in which the genes for other immunoglobulins are looped out to leave the IgE transcript next to the variable gene transcript.

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