Immunoglobin M

Ricin is a highly immunogenic toxin, and paired acute and convalescent sera should be obtained from survivors for measurement of antibody response. Conceptually, the detection of circulating antiricin antibodies formed in response to sublethal toxin exposure is possible for exposed individuals who survive for 2-3 weeks (Hunt et al., 1918). However, humoral immunoglobin M responses would likely be of short duration, and no immunological memory would be anticipated without boosting. 

Barnett, J.B., J.M. Spyker-Cranmer, D.L. Avery, and A.M. Hoberman. 1980. Immunocompetence over the lifespan of mice exposed in utero to carbofuran or diazinon. I. Changes in serum immunoglobin concentrations. Jour. Environ. Pathol. Toxicol. 4 53-63. 

IgE IgG IgM IL KLa KLH mAb PEG S-S TK tRNA Immunoglobin class E Immunoglobin class G Immunoglobin class M Interleukin Volumetric oxygen transfer coefficient keyhole limpet haemocyanin Monoclonal antibody polyethylene glycol Disulfide bridge thymidine kinase transcript of the RNA... 

Tan E, Hajinazarian M, Bay W, Neff J, Mendell, JR. Acute renal failure resulting from intravenous immunoglobin therapy. Arch Neurol 1993 50 137-139. 

Lam S, Tkn F, Chan H, Chan-Yeung M 1983 Relationship between types of asthmatic reaction nonspecific bronchial reactivity and specific immunoglobin E antibodies in patients with red cedar Thuja plicata asthma. J Allerg Clin Immunol 72 134-139... 

Tse K S, Chan H, Chan-Yeung M 1982 Specific immunoglobin in E antibodies in workers with occupational asthma due to western red cedar. Clin Allerg 12 249-258... 

D. Khare, P. Alexander, J. Antosiewicz, P. Bryan, M. Gilson, and J. Orban, Biochemistry, 36, 3580 (1997). pKa Measurements from Nuclear Magnetic Resonance for the B1 and B2 Immunoglobin G-Binding Domains of Protein G Comparison with Calculated Values for Nuclear Magnetic Resonance and X-Ray Structures. 

---