Immunodominant sidechains

Figure 3. Immunodominant sidechains in yeast mannoproteins. The curved lines indicate the antibody binding sites inferred from hapten inhibition studies. Refer to Figure 2 for the distribution of these determinants in different yeast mannoproteins.

Figure 6. Immunodominant sidechain structures illustrating the mannans from A, S. cerevisiae wild-type (25) B, C. utilis mutant (20). The curved lines indicate the presumed binding sites (11).

Rabbit antisera raised against intravenously injected whole yeast cells give strong precipitin reactions with isolated mannopro-teins (l6) and the homologous reactions can usually be inhibited by acetolysis fragments from the mannan (1T> l8, 195 20). Such studies revealed that the immunodominant structures of the yeast cell surface are the mannoprotein sidechains, and that some side-chains are more immunogenic than others (Figure 3). 

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