Immune-mediated neuropsychiatric

Neuropsychiatric symptoms are less frequent with subcutaneous aldesleukin (10). No predictive or predisposing factors have been clearly identified. Whether a direct effect of aldesleukin on neuronal tissues, an increased vascular brain permeability with a subsequent increased brain water content, or an aldesleukin-induced release of neuroendocrine hormones (beta-endorphin, ACTH, or cortisol), accounted for these effects, is unknown. A possible immune-mediated cerebral vasculitis has also been reported in one patient (SEDA-20, 334). 

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