Immune mediated idiosyncratic drug hypersensitivity

Sanner, M. A., Higgins, T. J. Chemical Basis for Immune Mediated Idiosyncratic Drug Hypersensitivity. In Ann. Rep. Med. Chem. 

Sanner, M.A. and Higgins, T.J. (1991) Chemical basis for immune mediated idiosyncratic drug hypersensitivity. In Bristol, J.A. (ed.). Annual Reports in Medicinal Chemistry, Vol. 26. Academic Press, San Diego. 

In some drug reactions, several of these hypersensitivity responses may present simultaneously. Some adverse reactions to drugs may be mistakenly classified as allergic or immune when they are actually genetic deficiency states or are idiosyncratic and not mediated by immune mechanisms (eg, hemolysis due to primaquine in glucose-6-phosphate dehydrogenase deficiency, or aplastic anemia caused by chloramphenicol). 

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