Immune cells endocannabinoid effect

Immune cells undergo dramatic metabolic and functional changes upon stimulation. The outcome of such stimulation depends on the type of stimuli and is specific for individual subsets of immune cells. Cannabinoids have been shown to have a marked deleterious effect on immune cell function (see reviews by Berdyshev, 2000 Roth et al., 2002 and Klein et al., 2003). In general, endocannabinoids follow the namral and synthetic cannabinoids in their ability to decrease immunogenic responses, but much more work is needed to clarify the regulatory mechanisms that link endocannabinoid metabolism with the functional outcomes of up- or dowmegulation of endocannabinoid production. 

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