Immediate postischemic

Dietrich W. D., Lin B., Globus M. Y., Green E. J., Ginsberg M. D., and Busto R. (1995) Effect of delayed MK-801 (dizocilpine) treatment with or without immediate postischemic hypothermia on chronic neuronal survival after global forebrain ischemia in rats. J. Cerebr. Blood Flow Metab. 15, 960-968. 

A study by Dietrich et al. (23) found that 3 h of immediate postischemic hypothermia (30°C) reduced CA1 loss at short (i.e., 3 and 7 d) but not long survival times (2 mo) after 10 min 2-VO ischemia in rats. Because all of the aforementioned studies (e.g., refs. 10-14) used short survival times, it was argued that postischemic hypothermia was, by itself, of no long-term benefit. Other work has confirmed the ephemeral nature of CA1 protection afforded by brief hypothermia (24). Likewise, a slow maturation of CA1 neuronal loss occurs following short duration (e.g., 5 min) 4-VO (vertebral cauterization + bilateral carotid artery occlusion) ischemia (25). In the 4-VO model the a-amino-3-hydroxy-... 

Studies in neonatal rats support these findings. For instance, Sirimanne et al. (58) persistently (21-d survival) reduced infarction in 21-d-old rats with 72 h of immediate postischemic mild hypothermia. Gunn et al. (59) reduced cortical infarction (5-d survival) in fetal sheep with the use of 72 h of mild in utero hypothermia induced 90 min after... 

The proinflammatory effects of HMGBl were studied in the postischemic brain of rats. Ischemia injury in the brain proceeds with excitotoxicity-induced acute neuronal cell death in the ischemic core, followed by delayed damage to the penumbra (Lee et al., 2000b). It was observed that HMGBl was immediately released into... 

---