Troleandomycin Imipramine

Clinically important, potentially hazardous interactions with alprazolam, amphetamines, astemizole, clarithromycin, clozapine, desipramine, dexibuprofen, dextroamphetamine, diethylpropion, droperidol, duloxetine, erythromycin, haloperidol, imipramine, isocarboxazid, linezolid, lithium, MAO inhibitors, mazindol, meperidine, methamphetamine, midazolam, moclobemide, nortriptyline, phendimetrazine, phenelzine, phentermine, phenylpropanolamine, phenytoin, pimozide, pseudoephedrine, selegiline, serotonin agonists, sibutramine, St John s wort, sumatriptan, sympathomimetics, tramadol, tranylcypromine, trazodone, tricyclic antidepressants, troleandomycin, tryptophan, zolmitriptan... 

Acetaminophen, aldrin, alfentanil, amiodarone, aminopyrine, amitriptyline, amprenavir, androstenedione,antipyrine, astemizole, benzphetamine, budesonide, carbamazepine, celecoxib, chlorpromazine, chlorzoxazone, cisapride, clarithromycin, clozapine, cocaine, codeine, cortisol, cyclophosphamide,cyclosporin, dapsone, delavirdine, dextromethorphan, digitoxin, diltiazem, diazepam, erythromycin, 17j3-estradiol, ethinylestradiol, etoposide, felbamate, fentanyl, flutamide, hydroxyarginine, ifosphamide, imipramine, indinavir, ketoconazole, lansoprazole, loratidine, losartan, lovastatin, (iS)"mephen3d in, methadone, mianserin, miconazole, mifepristone, nelfinavir, nevirapine, nicardipine, nifedipine, odansetron, omeprazole, orphenadrine, proguanil, propafenone, quinidine, quinine, rapamycin, retinoic acid, ritonavir, saquinavir, selegiline, serindole, sufentanil, sulfinpyrazone, tacrolimus, tamoxifen, tamsulosin, taxol, teniposide, terfenadine, tetrahydrocannabinol, theophylline, toremifene, triazolam, trimethadone, trimethoprim, troleandomycin, verapamil, warfarin, zatosetron, Zolpidem, zonisamide... 

Troleandomycin increases the plasma levels of imipramine, and an isolated report suggests that josamydn may possibly increase amitriptyline serum levels. Erythromycin may possibly raise clomipramine levels, but was not found to interact with other tricyclic antidepressants in one study. 

A study in 9 healthy Chinese men found that when they were given troleandomycin 250 mg daily for 2 days before a single 100-mg oral dose of imipramine, the AUC of the imipramine was increased by 59% and its oral clearance was reduced by 30%. It is thought that troleandomycin inhibits the V-demethylation of imipramine by inhibiting the cytochrome P450 isoenzyme subfamily CYP3A. The clinical importance of this interaction is uncertain, but it may be prudent to be alert for increased antimus-carinic adverse effects (e.g. dry mouth, blurred vision, urinary retention). 

Wang J-S, Wang W, Xie H-G, Huang S-L, Zhou H-H. Effect of troleandomycin on the pharmacokinetics of imipramine in Chinese tiie role of CYP3A BrJ Clin Pharmacol (y99T) 44, 195-8. 

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See also in sourсe #XX -- [ ]

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