Imidazoline binding structures

Dardonville C, Rozas I. Imidazoline binding sites and their ligands an overview of the different chemical structures. Med Res Rev 2004 24 639-661... 

Tolazoline (41) has clear structural similarities to the imidazoline a-agonists, such as naphazoline and xylometazoline, but does not have the lipophilic substituents required for agonist activity. Phentolamine (40) is also an imidazoline a-antagonist but the nature of its binding to a-adrenoceptors is not elearly understood. 

Fig. 15.5-6 Binding mode of c/s-imidazoline and p53 peptide. The structures of the c/s-imidazoline-hdm2 complex [60] and the p53-hdm2 complex...

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