Imidazoline binding sites

Parini A, Moudanos CG, PizzinatN, Lanier SM. The elusive family of imidazoline binding sites. Trends Pharmacol Sci 1996 17 13-16. 

Since imidazoline receptors are sub-classified, it is generally assumed that tritiated clonidine labels Ii-subtype of imidazoline binding sites while tritiated idazoxan is a useful tool to label l2-binding sites in this case, it is however necessary to check whether these sites are insensitive to unlabelled clonidine [20]. In order to investigate these latter sites a tritiated form of a more selective... 

Molderings GJ, Gothert M (1999) Imidazoline binding sites and receptors in cardiovascular tissue. Gen Pharmacol 32 17-22... 

Molderings, G.J., Gothert, M., 1991. Inhibitory presynaptic imidazoline receptors on sympathetic nerves in the rabbit aorta differ from I, - and 12-imidazoline binding sites. Naunyn-Schmiedeberg s Arch. Pharmacol. 351, 507-516. 

Tesson, F., Limon-Boulez, I., Urban, P., Puype, M Vandekerckhove, J. et al., 1995. Localization of 12-imidazoline binding sites on monoamino oxidases. J. Biol. Chem. 270, 681-688. 

Emsberger, P.R., Meeley, M.P., Mann, J.J., Reis, D.J., 1987. Clonidine binds to imidazoline binding sites as well as oj-adrenoceptors in the ventrolateral medulla. Eur. J. Pharmacol. 134, 113. 

Piletz, J.E., Sletten. K., 1993. Nonadrenergic imidazoline binding sites on human platelets. J. Pharmacol. Exp. Ther. 267, 1493-1502. 

Dardonville C, Rozas I. Imidazoline binding sites and their ligands an overview of the different chemical structures. Med Res Rev 2004 24 639-661... 

Harmane (2-methyl-p-carboline, l-methyl-9H-pyrido[3,4-A]indole, Aribine) ]486-84-0] M 182.2, m 235-238 , 237-238 , pKi 7.37 (basic. Pry N), pK214.7 (acidic, NH). CrystalUse it from heptane/cyclohexane. It is insoluble in H2O, but soluble in dilute HCl or H2SO4. Solutions show a blue fluorescence. Its UV (MeOH) has Aanax nm (log s) at 234 (4.57), 287 (4.21) and 347 (3.66). The hydrochloride forms needles from EtOH/dil HCl which sublimes at m 120-130 . It is an imidazoline binding site agonist. [Wolfbeis Monatsh Chem 113 509 1982, Beilstein 23/12 237.]... 

Major and minor sites of action alpha-2-adrenore-ceptors in the CNS and periphery, as well as non-adrenergic imidazoline binding sites. 

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