II Heteronuclear shift correlation

Correlations through the chemical bond II Heteronuclear shift correlation 

This chapter on establishing correlations through the chemical bond concentrates on techniques that correlate different nuclides, the so-called heteronuclear shift correlations. For an organic chemist, this means, in the vast majority of cases, establishing connectivities between proton and carbon nuclei, and as such the techniques encountered in the sections that follow are primarily concerned with these. That is, not to say that the techniques are not suitable for correlating other nuclides, for example, with or or even with and so on. Indeed many of the modern techniques used routinely in the chemical laboratory were originally implemented as methods for correlations in proteins and peptides. 

The principal techniques described in the sections that follow are summarised in Table 6.1. 

HMQC Correlating coupled heteronuclear spins across a single bond and hence identifying directly coimected nuclei, most often 

Employs detection of high-sensitivity nuclide, e.g. H, (an inverse technique ). Experimentally robust sequence, well suited to 

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