Identification of a Lead Series

Number of projects in which a compound hits Fig. 15.7 Analysis of selectivity of 2094 recent hits. 

The goal of the hit-to-lead process is to develop a hit or series of hits to the point where significant resources can be committed for lead optimization. Occasionally, a hit from 

Chemoinformatic Tools for Library Design and the Hit-to-Lead Process A User s Perspective 

The chemical attributes of a lead series include knowing the chemical structure and purity of the hit(s). There are often cases where the activity of a screening sample cannot be confirmed when the compound is resynthesized and this can sometimes be traced to impurities in the original sample, and there are cases where the structure of the hit was not assigned correctly. In order to justify the resources required for lead optimization, it is important to know the structure of the lead. Synthetic tractability can 

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