Telmisartan Ibuprofen

Stangier J, Su CA, Fraunhofer A, Tetzloff W. Pharmacokinetics of acetaminophen and ibuprofen when coadministered with telmisartan in healthy volunteers. J Clin Pharmacol 2000 40(12 Pt 1) 1338 6. 

Indometacin may attenuate the antihypertensive effect of losar-tan, valsartan, or other angiotensin II receptor antagonists. However, low-dose aspirin does not appear to alter the antihypertensive effect of losartan. No clinically relevant pharmacokinetic interactions occur between telmisartan and ibuprofen or paracetamol (acetaminophen), or between valsartan and indometacin. The combination of an NSAID and angiotensin II receptor antagonist can increase the risk of renal impairment and hyperkalaemia. 

In a crossover study in 12 healthy subjects, telmisartan 120 mg daily had no effect on the pharmacokinetics of ibuprofen 400 mg three times a day for 7 days. Similarly, the pharmacokinetics of telmisartan were unaffeet-ed by the concurrent use of ibuprofen, when compared with previous studies of telmisartan alone. ... 

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