Heart failure ibuprofen

Aspirin and ibuprofen Section 12.5.2 Digitalis and congestive heart failure Section 13.2.3 Multidrug resistance and cystic fibrosis Section 13.3 Protein kinase inhibitors as anticancer drugs Section 15.5.1... 

Apart from the consequences of salt and water retention, ibuprofen does not affect myocardial or vascular function. Congestive heart failure has rarely been reported (3). 

Ibuprofen and other NSAIDs, even in therapeutic doses, may precipitate symptoms of heart failure due to fluid retention in susceptible individuals. 

A case of heart failure with delirium was reported in a man with a significant history of cardiovascular disease who had taken valerian (500-2000 mg daily) for 5 years and was also taking numerous other medications and supplements (isosorbide dinitrate, digoxin, furosemide, benazepril, aspirin, lovastatin, ibuprofen, potassium, zinc, and vitamins). The reporting physicians stated that valerian is considered to exert a benzodiazepine-like action through the enhancement of y-aminobutyric acid neurotransmission they suggested that symptoms reported in this case were similar to benzodiazepine withdrawal symptoms and hypothesized that the cardiac failure was due to valerian withdrawal (Garges et al. 1998). 

ANTI-INFLVMMATORY AND ANTIPYRETIC ANALGESICS AND DRUGS USED IN GOUT TABLE 2 Effects of COX-2 Selective Inhibitors, Naproxen, Diclofenac and Ibuprofen on Major Vascular Events, Heart Failure Hospitalization, All-Cause Mortality and Upper Gastrointestinal Complications ... 

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