Ibogaine hydrochloride

The only study so far on the effects of ibogaine homologues in humans was done by P.B. Schmidt, who in 1967 reported on doses of 0.1 to 1.2 mg./kg. of ibogaine hydrochloride administered orally to twelve subjects. It produced states of inebriation and mild sedation with minor psychic changes. The dosage used by Schmidt may have been insufficient Chemical references, mainly in French, are listed at the end of Pope s paper in Economic Botany (April-June 1969). 

Infra-red Spectrum. Principal peaks at wavenumbers 1490,1210, 1140, 810, 1020, 835 (ibogaine hydrochloride, KBrdisk). 

A single treatment with ibogaine or ibogaine hydrochloride administered orally at a dosage ranging from 6 mg/kg to 19 mg/kg... 

Because of these two separate and largely inaccessible chiral centers there are, in theory, four distinct isomers of ibogaine which are difficult to resolve. When the term "synthetic" is used in regard to ibogaine in the scientific journals, it usually applies to the resynthesis of the parent alkaloid from the demethylated metabolite. For reference purposes, here are the finger print number from the infrared spectra For the free base IR (in cm-1) 741, 799, 830, 1037, 1111, 1148 mp 152-153 °C. For the hydrochloride salt IR (in cm-1) 638, 810, 832, 925, 1031, 1149 mp 299-300 °C (dec). 

---