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IB-MECA

A3 Lung, liver, brain, testis, heart IB-MECA, 2-CI-IB-MECA, DBXRM, VT160 MRS 1220, L-268605, MRS1191, MRS 1523, VUF8504 Gj/o Gq/n fcAMP TIP3... [Pg.1049]

CPX, 1,3-dip ropyl-8-cyclopentylxanthine MRE3008F20,5N-(4-methoxyphenylcarbamoyl)amino-8-propyl-2-(2-furyl)pyrazolo[4,3-e]-1,2,4-triazolo[l,5-c]pyrimidine (human only) NECA, 5 -N-ethylcarboxamidoadenosine SPT,p-sulfophenyltheophylline SCH58261, 5-amino-7-(2-phenylethyl)-2-(2-furyl)-pyrazolo-[4,3-8]-l,2,4-triazolo[l,5-c)pyrimidine IB-MECA N6-(2-iodo)benzyl-5 -N-methylcarboxami-dodiadenosine ZM241385,4-(2-[7-amino-2-[2-fhryl] [l,2,4]triazolo[2,3-a] [l,3,5]triazin-5-yl-amino]ethyl)phenol. [Pg.310]

Fig. 1.3 The effect of QAF805 on the cardiovascular response to 2-C1-IB-MECA in the rat. Shown are the blood pressure (BP) and heart rate (HR) changes induced by 2-C1-IB-MECA (50, 100, 200 and 400 ug kg-1 cumulative i.v.). Vehicle or QAF805 was given orally 1 h prior to Cl-IB-MECA. Results are expressed as means s.e. mean from n individual animals (J.R. Fozard and... Fig. 1.3 The effect of QAF805 on the cardiovascular response to 2-C1-IB-MECA in the rat. Shown are the blood pressure (BP) and heart rate (HR) changes induced by 2-C1-IB-MECA (50, 100, 200 and 400 ug kg-1 cumulative i.v.). Vehicle or QAF805 was given orally 1 h prior to Cl-IB-MECA. Results are expressed as means s.e. mean from n individual animals (J.R. Fozard and...
Fig. 1.4 The bronchoconstrictor effects of adenosine, NECA, CPA, CGS 21680 and 2-C1-IB-MECA in actively sensitised, Brown Norway rats 3 h post intratracheal instillation of vehicle (saline, 0.2 ml) or ovalbumin (OA, 0.3 mg kg-1). The agonists were given i.v. and to avoid tachyphylaxis, only one response was generated per animal. Results are expressed as means s.e. means (n = 4—5). P < 0.01, P < 0.001 that the value is significantly different from the equivalent value in the vehicle-challenged group (from Hannon et al. 2002b, with permission)... Fig. 1.4 The bronchoconstrictor effects of adenosine, NECA, CPA, CGS 21680 and 2-C1-IB-MECA in actively sensitised, Brown Norway rats 3 h post intratracheal instillation of vehicle (saline, 0.2 ml) or ovalbumin (OA, 0.3 mg kg-1). The agonists were given i.v. and to avoid tachyphylaxis, only one response was generated per animal. Results are expressed as means s.e. means (n = 4—5). P < 0.01, P < 0.001 that the value is significantly different from the equivalent value in the vehicle-challenged group (from Hannon et al. 2002b, with permission)...
As mentioned above, a key factor in excluding a role for three out of the four recognised adenosine receptor subtypes was that the subtype selective agonists, CPA (Aj), CGS 21680 (A2A) and 2-CI-IB-MECA (A3), unlike the non-selective agonists,... [Pg.17]

Fig. 1.6 Effect of adenosine, CPA and 2-C1-IB-MECA at the concentrations indicated on lung parenchymal strips prepared from actively sensitised Brown Norway rats 3 h post intratracheal instillation of ovalbumin (0.3 mg kg 1 filled columns) or saline (open columns). Responses are expressed relative to the response to bethanechol (100 pM) which was taken as 100%. Mean values ( SEM) from the number of individual experiments shown in parentheses are presented. P < 0.05, P < 0.001 that the value differs significantly from the equivalent value in the saline challenged group (from Wolber and Fozard 2005, with permission)... Fig. 1.6 Effect of adenosine, CPA and 2-C1-IB-MECA at the concentrations indicated on lung parenchymal strips prepared from actively sensitised Brown Norway rats 3 h post intratracheal instillation of ovalbumin (0.3 mg kg 1 filled columns) or saline (open columns). Responses are expressed relative to the response to bethanechol (100 pM) which was taken as 100%. Mean values ( SEM) from the number of individual experiments shown in parentheses are presented. P < 0.05, P < 0.001 that the value differs significantly from the equivalent value in the saline challenged group (from Wolber and Fozard 2005, with permission)...
DPCPX CI-IB-MECA Methysergide CI-IB-MECA DPCPX CI-IB-MECA... [Pg.19]

Ge Z-D, Peart JN, Kreckler LM, Wan TC, Jacobson MA, Gross GJ, Auchampach JA (2006) (Cl-IB-MECA (2-chloro-((lV5-(3-iodobenzyl)adenosine)-5 - /V-methyl carboxamide) reduces ischemia/reperfusion injury in mice by activating the Aj adenosine receptor. J Pharmacol Exp Ther 319 1200-1210... [Pg.25]

Smith SR, Denhardt G, Terminelli C (2002) A role for histamine in cytokine modulation by the adenosine A3 receptor agonist 2-C1-IB-MECA. Eur J Pharmacol 457 57-69 Tilley SL, Wagoner VA, Salvatore CA, Jacobson M, Koller BH (2000) Adenosine and inosine increase cutaneous vasopermeability by activating A(3) receptors on mast cells. J Clin Invest 105 361-367... [Pg.26]

ERK1/2 phosphorylation by involving G /o proteins, PKC and tyrosine kinase-dependent and -independent pathways. It has been found that Cl-IB-MECA produced a biphasic effect on cAMP accumulation with a stimulatory action starting at a concentration of 3 nM. This activity was triggered through PLC/PKC and not via direct Gs coupling (Germack and Dickenson 2004, 2005). [Pg.65]

Englert M, Quitterer U, Klotz KN (2002) Effector coupling of stably transfected human A ) adenosine receptors in CHO cells. Biochem Pharmacol 64(l) 61-65 Fishman P, Madi L, Bar-Yehuda S, Barer F, Del Valle L, Khalili K (2002) Evidence for involvement of Wnt signaling pathway in IB-MECA mediated suppression of melanoma cells. Oncogene 21(25) 4060-4064... [Pg.70]

Fishman P, Bar-Yehuda S, Madi L, Rath-Wolfson L, Ochaion A, Cohen S, Baharav E (2006) The PI3K-NF-kappaB signal transduction pathway is involved in mediating the anti-inflammatory effect of IB-MECA in adjuvant-induced arthritis. Arthritis Res Ther 8(1) R33 Fossetta J, Jackson J, Deno G, Fan X, Du XK, Bober L, Soude-Bermejo A, de Bouteiller O, Caux C, Lunn C, Lundell D, Palmer RK (2003) Pharmacological analysis of calcium responses mediated by the human A3 adenosine receptor in monocyte-derived dendritic cells and recombinant cells. Mol Pharmacol 63(2) 342-350... [Pg.70]

Tracey WR, Magee W, Masamune H, Oleynek JJ, Hill RJ (1998) Selective activation of adenosine A3 receptors with N6-(3-chlorobenzyl)-5 -N-methylcarboxamidoadenosine (Cl-IB-MECA) provides cardioprotection via KATP channel activation. Cardiovasc Res 40( 1) 138—145... [Pg.74]

See other pages where IB-MECA is mentioned: [Pg.25]    [Pg.310]    [Pg.311]    [Pg.8]    [Pg.10]    [Pg.13]    [Pg.14]    [Pg.15]    [Pg.16]    [Pg.17]    [Pg.18]    [Pg.18]    [Pg.20]    [Pg.20]    [Pg.20]    [Pg.21]    [Pg.21]    [Pg.22]    [Pg.22]    [Pg.23]    [Pg.26]    [Pg.36]    [Pg.37]    [Pg.37]    [Pg.49]    [Pg.50]    [Pg.63]    [Pg.64]    [Pg.65]    [Pg.66]    [Pg.66]    [Pg.67]    [Pg.79]    [Pg.81]    [Pg.93]   
See also in sourсe #XX -- [ Pg.155 , Pg.156 , Pg.158 ]



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