Hysodricanine

From the roots of Zizyphus mucronata, in addition to the known alkaloid mucronine D (23), two new cyclopeptide alkaloids 24 and 25 were isolated. The structures were elucidated by ID- and 2D-NMR techniques (48). A new cyclopeptide alkaloid, named mucronine J (53), was isolated together with known alkaloids abyssenine A and mucronine D (23) from the methylene chloride extract of the root bark of Z. mucronata (49). The structure of mucronine J was elucidated by mass spectrometry and ID and 2D-NMR techniques, and the solution conformation is proposed on the basis of NOE experiments in combination with MM2 calculations. Leaves of Zizyphus hysodrica were extracted with methanol and the different alkaloidal fractions gave a new compound, hysodricanine B, which is a cyclopeptide alkaloid (50). 

Of the seven alkaloids isolated from Ziziphus hysodrica, only one is new, namely hysodricanine A (25). In the same publication, an investigation into the bark of Ziziphus mauritiana has included the isolation of the known alkaloids mauritines A—F and G together with the new alkaloid mauritine H (26). Araliorham-nus vaginata was shown to contain a new aralionin-type alkaloid C (27) as well as the previously reported A, B, and desbenzyl-aralionin A compounds. ... 

Tschesche, R., D. Hillebrand, H. Wilhelm, E. Ammermann, and G. Eckhardt Hysodricanin-A, Mauritin-H, Scutianin-F und Aralionin-C, vier weitere Cyclo-peptidalkaloide aus Zizyphus, Scutia und Araliothamnus. Phytochemistry, 16, 1025 (1977). 

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