Hyptis verticillata

The dichloromethane extract of Hyptis verticillata (Lamiaceae) yielded the sesquiterpene cadina-4,10(15)-dien-3-one, Fig. (2) [142]. Besides its insecticidal activity against Cylas formicarius, this chemical inhibited the... 

M Novelo, JG Cruz, L Hernandez, R Pereda-Misanda, H Chai, W Mar, JM Pezzuto. Cytotoxic constituents from Hyptis verticillata. J Nat Prod 56 728-1736, 1993. 

Constit. of Hyptis verticillata (Labiatae). [a]p + 77.0 (CHCI3). Isomer of a-Apopicropodophyllin, A-02613. 

Squamulosone (77), aromadendr-l(lO) en 9 one isolated from Hyptis verticillata (Labiatae), was reduced chemically to give 78-82, which were incubated with the fungus Curvularia lunata in two different growth media (Figure 20.28). 

Cadina-4,10(15)-dien-3-one (265) possessing insecticidal and ascaricidal activity, from Jamaican medicinal plant Hyptis verticillata was metabolized by Curvularia lunata. ATCC 12017 in potato dextrose to give its 12-hydoxy- (266), 3a-hydroxycadina-4,10(15)-dien (267), and 3a-hydroxy-4,5-dihydrocadinenes (268) while 265 was incubated by the same fungus in peptone, yeast, and beef extracts and glucose medium, only 267 and 268 were obtained. Compound 267 derived synthetically was treated in the same fungus Curvularia lunata to afford three metabolites (269-271) (Collins and Reese, 2002) (Figure 15.82). 

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