Reactive oxygen species hypoxia-ischemia

Free radical formation is an important contributor to cell death and brain injury in many neurological diseases. Shortly after brain damage by hypoxia-ischemia, hemorrhage, or trauma, excessive reactive oxygen species (ROS) production occurs, and at the same time, there is an impairment of antioxidant protective mechanisms, which leads to oxidative stress (Heo et al 2005). 

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