Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Hypoxia-Inducible Factor-Dependent Pathway

A representation of hypoxia-inducible factor (HIF) function. In normoxia, HIF Ia is broken down after prolyl hydroxylation and its interaction with p300 is diminished after aspargyl hydroxylation. In hypoxia, hydroxylase enzymes are inhibited, whereby the DNA binding of HIF may occur and oxygen-sensitive genes can be induced [Pg.281]

HIF hydroxylated to asparagine does not form a complex with p300 whereby its DNA binding is inhibited [Pg.281]

Huang, L.E., J. Gu, M. Schau, and H.F. Bunn (1998). Regulation of hypoxia-inducible factor 1 alpha is mediated by an 02-dependent degradation domain via the ubiquitin-proteasome pathway. Proc. Natl. Acad. Sci. USA 95 7987-7992. [Pg.154]

Members of the a-ketoglutarate-dependent dioxygenase family are involved in a number of biosynthetic pathways, and have recently been implicated in mammalian oxygen sensing by hypoxia inducible factor (HIF), via hydroxylation of Pro-402, Pro-564, and Asn-803 of HIF-la. ... [Pg.615]

Mateo, J., Garcia-Lecea, M., Cadenas, S., Hernandez, C., and Moncada, S. (2003). Regulation of hypoxia-inducible factor-la by nitric oxide through mitochondria-dependent and -independent pathways. Biochem. J. 376, 537-544. [Pg.355]

See other pages where Hypoxia-Inducible Factor-Dependent Pathway is mentioned: [Pg.280]    [Pg.280]    [Pg.634]    [Pg.83]    [Pg.375]    [Pg.47]    [Pg.16]    [Pg.374]    [Pg.429]    [Pg.191]    [Pg.47]    [Pg.321]    [Pg.48]    [Pg.412]    [Pg.725]    [Pg.12]    [Pg.282]    [Pg.280]    [Pg.83]    [Pg.891]    [Pg.23]    [Pg.143]    [Pg.187]    [Pg.284]    [Pg.288]    [Pg.581]    [Pg.283]    [Pg.276]    [Pg.17]    [Pg.14]    [Pg.269]   


SEARCH



Dependent Pathways

Hypoxia inducible factor

Hypoxia-inducing factor

Inducing factors

© 2024 chempedia.info