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Hypoxanthine desoxyriboside

Manson and Lampen243 reported that they obtained the phosphorolysis and arsenolysis of hypoxanthine desoxyriboside by enzyme preparations from calf-thymus gland and rat liver. An acid-stable phosphate ester was isolated as a product of phosphorolysis. Results to be outlined suggested that this ester was 2-desoxy-D-ribose 5-phosphate and evidence was obtained for its formation by a mutase type reaction from 2-desoxy-D-ribose 1-phosphate. This evidence was extended and reinforced when Manson and Lampen244 obtained indications for the formation of desoxy-D-ribose 1-phosphate during the phosphorolysis of thymidine. Consequently the conversions outlined may be depicted as shown. [Pg.103]

Desoxyribose-l-phosphate has been obtained as the crystalline cyclo-hexylamine salt. It is even more acid-labile than ribose-l-phosphate. Thus, 50% of the phosphorus is released as inorganic phosphate within 10 to 15 minutes upon hydrolysis at pH 4, at 23°C. The equilibrium favors synthesis. It is felt that the same enzyme catalyzes the phosphorolysis of hypoxanthine riboside and hypoxanthine desoxyriboside, because the Michaelis-Menten constants are nearly identical and there is no summation of rates with both substrates present at optimal concentrations. Furthermore, nucleoside phosphorylase purified from horse liver is active with both nucleosides and desoxynucleosides. ... [Pg.266]

Adenine + hypoxanthine desoxyriboside hypoxanthine + adenine desoxyriboside Thymine + hypoxanthine desoxyriboside hypoxanthine + thymine desoxyriboside... [Pg.269]

Uracil hypoxanthine desoxyriboside hypoxanthine + uracil desoxyriboside Adenine + uracil desoxyriboside uracil + adenine desoxyriboside... [Pg.269]

The desoxyribose-5-phosphate generated enzymatically as described above has been converted to hypoxanthine desoxyriboside in extracts of E. coli in two reactions, analogous to the phosphoribomutase and nucleoside phosphorylase reactions. These are ... [Pg.216]


See other pages where Hypoxanthine desoxyriboside is mentioned: [Pg.51]    [Pg.65]    [Pg.284]    [Pg.320]    [Pg.266]    [Pg.270]    [Pg.270]    [Pg.216]    [Pg.51]    [Pg.65]    [Pg.284]    [Pg.320]    [Pg.266]    [Pg.270]    [Pg.270]    [Pg.216]    [Pg.233]   
See also in sourсe #XX -- [ Pg.283 ]

See also in sourсe #XX -- [ Pg.216 ]




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