Hypotensive peptides pharmacology

Kinins have been classified as hypotensive peptides resembling bradykinin in both structure and pharmacologic activity (1). 

Sublimaze fentanyl. substance K neurokinin A neuropeptide K. substance P (SP) is a naturally occurring 11 amino acid residue C-terminally amidated peptide, and is a tachykinin present in the brain of vertebrate species, in spinal ganglia and in the intestines. It is formed from the precursor preprotachykinin A (PPT-A). It acts as a tachykinin RECEPTOR AGONIST and Stimulates extravascular smooth muscle, is a powerful VASODILATOR and transient HYPOTENSIVE, and causes salivation and increased capillary permeability. Notably, Af-terminally deleted fragments (e.g. SP(4-11)) are as active as substance P itself on many systems. It is used as a pharmacological tool. 

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