Hypotension doxycycline

Typhus fever B (Rickeffsia prowazekii) Insects— arthropods (primarily human lice) animals— flying squirrels in the US typically has been seen 1-2 weeb, typically 12 days No (but infected lice can be transferred) Standa d High fever, rash (w/in 6 days), muscle pain, hypotension, photophobia, delirium Typically 2 weeks in untreated pts hat recover Doxycycline, chloramphenicol... 

Rapid i.v. administration of tetracyclines can result in hypotension and collapse. This has been attributed to intravascular chelation of calcium and/or a decrease in blood pressure owing to the drug vehicle. The i.v. administration of doxycycline to horses causes tachycardia, systemic arterial hypertension, collapse and death. This reaction may be caused by the highly lipid-soluble doxycycline chelating intracellular calcium, resulting in cardiac neuromuscular blockade. 

Immunologic A Jarisch-Herxheimer reaction occurred four times in a 36-year-old man with Q fever pneumonia after treatment with doxycycline, with an acute rise in temperature, tachycardia, tachypnea, hypoxia, hypotension, and temporary deterioration of the chest x-ray on each occasion the reaction lasted for 6 hours [124 ]. 

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