Hypoplastic left heart syndrome

Y. Jiang, S. Habibollah, K. Tilgner, J. Collin, T. Barta, J. Y. Al-Aama, L. Tesarov, R. Hussain, A. W. Trafford, G. Kirkwood, An induced pluripotent stem ceU model of hypoplastic left heart syndrome (HLHS) reveals multiple expression and functional differences in HLHS-derived cardiac myocytes. Stem Cells Transl Med 3, 416-423 (2014). 

The Heart Institute of Childrens Hospital Los Angeles is part of a fifteen-member consortium of pediatric cardiac institutes called the Pediatric Heart Network. Its research focus is the optimal survival of babies bom with hypoplastic left heart syndrome, in which the left ventricle is missing or underdeveloped without corrective surgery, the condition is fetal. 

B. A. Johnson, G. M. Hoffman, J. S. Tweddell, J. R. Cava, M. Basir, M. E. Mitchell, M. C. Scanlon, K. A. Mussatto, and N. S. Ghanayem, Near-Infrared Spectroscopy in Neonates before Palliation of Hypoplastic Left Heart Syndrome, Amm. Thorac. Surg., 87, 571 (2009). 

The operative cardiac transplant technique is nearly the same as described above adapted to the underlying congenital disease. In hypoplastic left heart syndrome hypothermic circulatory arrest is necessary to enable the aortic anastomosis and reconstruction of the aortic arch using donor tissue. 

Razzouk AJ, Chinnock RE, Gundry SR et al (1996) Transplantation as primary treatment for hypoplastic left heart syndrome intermediate-term results. Ann Thorac Surg... 

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