Hypohidrosis

Symptoms Retention hyperkeratosis on extremities better in summer Brown scales all over the body associated features maternal pregnancy abn. Collodion baby generalized scaling large, thick scales ektropion hypohidrosis Intense blistering at birth later verrucous hyperkeratosis, esp. in body folds keratoderma ... 

Because sweating is mediated by sympathetic innervation, interruption of these fibers results in fecial or body anhidrosis or hypohidrosis. However, lesions involving the postganglionic sympathetic pathway generally cause Horner s syndrome without anhidrosis. The presence of... 

Areas J, Ferrer T, Roche MC, Martinez-Bermejo A, Lopez-Martin V. Hypohidrosis related to the administration of topiramate to children. Epilepsia 2001 42(10) 1363-5. 

Human sweating is minimal (about 350ml/24h) under a subject-specific sweat threshold, but increases to values up to several liters per hour during exercise. The maximum sweat rate recorded is 3.7 1/h from Alberto Salazar (Armstrong et al., 1986). An important heat strain indicator is the sweat efficiency, defined as the ratio of evaporated versus produced sweat. In protective clothing, the sweat efficiency is low and heat strain is imminent. In windy, hot dry environments, sweat efficiency can become close to 100% and humans can cool efficiently. Subjects with sweat abnormalities such as hypohidrosis or anhidrosis are not able to produce sufficient sweat to cool and may have additional health risks in the heat. The sweat efficiency is the basis of the ISO standard 7933 (Malchaire, 2006). 

Sweat glands Hypohidrosis and hyperthermia are uncommon adverse reactions to topiramate and usually occur in children with epilepsy. Reversible hypohidrosis has been reported in an adult taking topiramate for chronic migraine [297 ]. 

Of 151 children with epilepsy, mean age 33 months, taking topiramate, 59 had symptoms related to hypohidrosis, such as facial flushing, lethargy, pruritus, irritability with hyperthermia, or heat intolerance [298 ]. 

Kim SC, Seol IJ, Kim SJ. Hypohidrosis-related symptoms in pediatric epileptic patients with topiramate. Pediatr Int 2010 52(1) 109-12. 

Margari L, Ventura P, Buttiglione M, Presicci A, Lucarelli E, Sardaro M, Di Fruscolo O, de Tommaso M. Electrophys-iological study in 2 children with transient hypohidrosis induced by topiramate. Clin Neuropharmacol 2008 31(6) 339-46. 

Karachristianou S, Papamichalis E, Sarantopoulos A, Boura P, Georgiadis G. Hypohidrosis induced by topiramate in an adult patient. Epileptic Disord June 2013 15(2) 203-6. 

---