Hypersensitivity proton pump inhibitors

The proton pump inhibitors are contraindicated in patients who have hypersensitivity to any of the drags. Omeprazole (Pregnancy Category C) and lansoprazole, rabeprazole, and pantoprazole (Pregnancy Category B) are contraindicated during pregnancy and lactation. The proton pump inhibitors are used cautiously in older adults and in patients with hepatic impairment. 

Bonadonna P, Lombardo C, Bortolami O, et al. Hypersensitivity to proton pump inhibitors diagnostic accuracy of skin tests compared to oral provocation test. J Allergy Clin Immunol. 2012 130 547-9. 

Chang YS. Hypersensitivity reactions to proton pump inhibitors. Curr Opin Allergy CUn Immunol. 2012 12 348-53. 

Pirson F, Geubel A, Marot L. Late hypersensitivity to omeprazole and other proton pump inhibitors. Acta Clin Belg 2012 67 301-3. 

Karabacak E, Kutlu A, Aydin E, Ozturk S. Hypersensitivity to lansoprazole with tolerance to other proton pump inhibitors does crossreactivity between proton pump inhibitors really exist AUergol Immunopathol Madr 2013 41 136-7. 

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