Hyperplasia progression from

Renal Effects. Exposure to lead that results in PbB ranging from approximately 60 to >100 pg/dL has been associated with nephropathy in some studies of lead-exposed workers (e.g., Chia et al. 1995a). The characteristics of early or acute lead-induced nephropathy in humans include nuclear inclusion bodies, mitochondrial changes, and cytomegaly of the proximal tubular epithelial cells dysfunction of the proximal tubules (Fanconi s syndrome) manifested as aminoaciduria, glucosuria, and phosphaturia with hypophosphatemia and increased sodium and decreased uric acid excretion. These effects appear to be reversible. Characteristics of chronic lead nephropathy include progressive interstitial fibrosis, dilation of tubules and atrophy or hyperplasia of the tubular epithelial cells, few or no nuclear inclusion bodies,... 

Lymphadenitis mimicking Hodgkin disease has been described as a benign lymphadenopathy that can mimic interfollicular HL.11 420 Cervical lymph nodes are affected most often. There is no progression to lymphoma. The lymph nodes show follicular hyperplasia with a mottled interfollicular zone with epithelioid histiocytes, lymphocytes, eosinophils, and immuno-blasts. Some immunoblasts with prominent nucleoli resemble H/RSCs. However, their nucleoli are typically smaller and basophilic, in contrast to the eosinophilic nucleoli of H/RSCs. Immunohistochemistry distinguishes this disorder from interfollicular HL because... 

In the Wistar rat, the proportion of C-cells to follicular cells was 4.5 % on the day of birth and increased progressively to 10.4 % by 120 days (MartIn-Lacave et al. 1992). The highest density of C-cells was noted in the mid-region of the lobes along a longitudinal axis. From 3 to 24 months of life, 27.5 % of female rats showed a normal C-cell pattern, 55.0% showed C-cell hyperplasia and 17.5 % showed C-cell tumours while 57.5 % of male rats showed a normal C-cell pattern, 32.5 % showed C-cell hyperplasia, and 10 % showed C-cell tumours (MartIn-Lacave etal. 1999). 

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