Hyperlipidemia drug-induced

Compared with previously available therapy, the adverse effects associated with cyclosporine are much less severe but still worthy of concern. Nephrotoxicity, which can occur in up to 75% of patients, ranges from severe tubular necrosis to chronic interstitial nephropathy. This effect is generally reversible with dosage reduction. Vasoconstriction appears to be an important aspect of cyclosporine-induced nephrotoxicity. Hypertension occurs in 25% of the patients and more frequently in patients with some degree of renal dysfunction the concomitant use of antihypertensive drugs may prove useful. Hyperglycemia, hyperlipidemia, transient liver dysfunction, and unwanted hair growth are also observed. 

Hyperlipidemia associated with antipsychotic drugs has been reviewed (SEDA-29, 64). Haloperidol and the atypical antipsychotic drugs ziprasidone, risperidone, and aripiprazole would be associated with lower risks of hyperlipidemia, whereas chlorpromazine, thioridazine, and the atypical drugs quetiapine, olanzapine, and clozapine would be associated with higher risks. However, severe clozapine-induced hypercholesterolemia and hypertriglyceridemia has been reported in a patient taking clozapine (55). 

Eritadenine is approximately ten times as potent as clofibrate in rats. Dietary hypercholesterolemia was suppressed by eritadenine but limited effects on Triton-induced hyperlipidemia were observed. The oral route of administration appears to produce superior lipid reductions and the drug causes a limited but significant enhancement in the rate of removal of cholesterol from the plasma compartment.65... 

Photodecarboxylation of 2-(3-benzoyl)phenylpropionate, the ketoprofen anion, was studied in water by time-resolved, laser-induced optoacoustic spectroscopy (LIOAS). The various transient species involved in the title reaction were identified and their Hfetimes measured. The intrinsic photoreactivity of the 2-benzoylthiophene chromophore of the photosensitizing drug, tiaprofenic acid, was also studied. The observed photoprocesses account readily for the biological photosensitization reactions such as membrane damage and protein modification. The transient photochemistry in photodecarboxylation of rufloxacin (a fluoroquinolone antibacterial drug), fenofibric acid (used in the treatment of hyperlipidemia), and tohnetin has also been reported. 

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