Hyperkalaemia drug-induced

Drugs that can disturb fluid-electrolyte balance must be used with caution in patients with certain types of liver impairment. Diuretics, for example, are often required to treat ascites but can cause hypo-natraemia, hypo- or hyperkalaemia. A disturbance in electrolyte balance can lead to encephalopathy in susceptible patients such as cirrhotics or those with acute liver failure. Dehydration induced by diuretics is a common precipitant of hepatic encephalopathy. The mechanism is not fully understood, but could possibly be due to the reduced metabolism of hepatic toxins because of hepatic hypoxia [5]. 

CICLOSPORIN CO-TRIMOXAZOLE Exacerbates hyperkalaemia induced by ciclosporin Additive effect Monitor serum potassium levels during co-administration >- For signs and symptoms of hyperkalaemia, see Clinical Features of Some Adverse Drug Interactions, Hyperkalaemia... 

Perazella MA. Trimethoprim-induced hyperkalaemia clinical data, mechanism, prevention and management. Drug Saf 2000 22(3) 227-36. 

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