Hyperhomocysteinemia genetic predisposition

Rozen R (1997) Genetic predisposition to hyperhomocysteinemia deficiency of meth-ylenetetrahydrofolate reductase (MTHFR). Thrombosis and Haemostasis 76, 523-6. 

Some 10-25% of the population have a genetic predisposition to hyperhomocysteinemia, which is a risk factor for atherosclerosis and coronary heart disease, as a result of polymorphisms in the gene for methylenetetrahydrofolate reductase. There is no evidence that supplements of vitamin Bg reduce fasting plasma homocysteine in these subjects, and like the tryptophan load test, the methionine load test may be an appropriate index of status in controlled depletion/repletion studies to determine vitamin Bg requirements, but not in population studies. 

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See also in sourсe #XX -- [ ]

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