Hyperglycemic activity

Drug interactions InsuUn requirements may be increased by medications with hyperglycemic activity such as corticosteroids, isoniazid, certain lipid-lowering drugs (e.g., niacin), estrogens, oral contraceptives, phenothiazines, and thyroid... 

AMP is related to certain mental diseases and may be involved in the action of tranquilizers and antidepressant drugs (60). Whether the ability of diuretic agents such as ethacrynic acid and chlorthalidone to inhibit the enzyme in kidney (68) is related to their diuretic action is also not known. It has been suggested that inhibition of diesterase by diazoxide (59) may explain the hyperglycemic activity of this agent. Several materials are known to activate the enzyme. Imidazole produces strong activation of the enzyme from mammalian tissues (36, 38, 42) but not from E. coli (41). It has been reported (61) that insulin activates the beef heart enzyme in vitro, but it is not known if this has relevance... 

Azadirachla indica A Juss (Meliaceae) Leaves (India) Possible mechanism of anti-hyperglycemic activity of Azadirachla indica leaf extract in diabetic and normal rabbits was studied [129]. 

In humans, eosinopenic and hyperglycemic potencies are essentially the same. There Is a close correlation in efficacy ratios derived from these tests and antirheu-matic potency (Table 33.6). Because the eosinopenic-hyperglycemic activity and antirheumatic potency show excellent agreement, it has been suggested that these assays afford advantages in the preliminary estimation of anti-inflammatory potency (27). 

Scarborough, R. M., Jamieson, G. C., KaHsh, F., Kramer, S. J., McEnroe, G. A., Miller, C. A., Schooley, D. A. (1984) Isolation and primary structure of two peptides with cardioacceleratory and hyperglycemic activity from the corpora cardiaca of Periplanaa americana. Proc Natl Acad Sci USA, 81, 5575-5579... 

Anti-hyperglycemic activity of the aqueous extract of Origanum vulgare growing wild in Tafilalet region. 2004. J Ethnopharmacol, 92, 251-256. 

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