Hyper-aldosteronism

Other unusual conditions that suggest aldosterone excess or deficiency but are not connected to the renin-angiotensin-aldosterone system include Liddle s syndrome (pseudo hyper aldosteronism),which resembles primary aldosteronism clinically, but aldosterone production is low and hypertension is absent and Barttefs syndrome,which involves a prostaglandin-mediated renal potassium wasting and renal chloride handling defect, in which both aldosterone concentrations and renin activities are elevated. In renal tubular acidosis and pseudohypoaldosteronism, the clinical picture of hypoaldosteronism is seen concurrent with greater-than-normal concentrations of aldosterone. 

Opocher G, Rocco S, Carpene G, Armanini D, Mantero F. Primary hyper aldosteronism. Minerva Endocrinol 1995 20 49-54... 

It acts both as a diuretic and as an antihypertensive drug. It is mostly employed in the treatment of refractory oedema associated with congestive heart failure, nephrotic syndrome or cirrhosis of the liver in which secretion of aldosterone plays a part. It has also been used successfully in the treatment of primary hyper aldosteronism. 

Goodfriend TL. Aldosterone—a hormone of cardiovascular adaptation and maladaptation. J Clin Hyper-tens. 2006 8 133-139. 

NSAIDs ANTICOAGULANTS-PARENTERAL 1. Risk of prolonged bleeding when ketorolac is co-administered with dalteparin (but not enoxaparin), and intravenous diclofenac is given with heparins 2. t risk of hyper-kalaemia when ketorolac is given with heparin f. Uncertain 2. Heparin inhibits aldosterone secretion, causing hyperkalaemia 1. Avoid co-administration 2. Monitor potassium levels closely... 

Losartan blocks the vascular constrictor effect of Ang II, the Ang Il-induced aldosterone synthesis and/or release, and the All-induced cardiovascular growth. In various models of experimental hypertension, losartan prevents or reverses the elevated blood pressure and the associated cardiovascular hypertrophy similar to angiotensin converting enzyme (ACE) inhibitors. Subsequently con-tolled clinical trials revealed that losartan is a new and valuable drug for treatment of hyper-... 

R, Connell JM (2002) Variation atthe aldosterone- 2138. synthase (CYP11B2) locus contributes to hyper-... 

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