Hygroscopic drug

X. Zhou, P.A. Hines, and M.W. Borer, Moisture determination in hygroscopic drug substances by near infrared spectroscopy, J. Pharm. Biomed. Anal, 17, 219-225 (1998). 

Thies, R. Kleinebudde, P. Melt pelletisation of a hygroscopic drug in a high shear mixer part 1. Influence of process variables. Int. J. Pharm. 1999, 188, 131-143. 

For example, in the drying of a hygroscopic drug compound, the residual solvent profile depends strongly on the relative humidity level in the vapor phase. Figure 2-26 shows the... 

The sodium salt of 3-(((3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)((3-dimethylamino)-3-oxo-propyl)thio)propanoic acid represents an unusual case of a hygroscopic drug substance, where the surface-active substance (in both crystalline and lyophilized forms) produced nonflowing, semisolid masses with exposure to increasing relative humidity [29]. The substance was shown to form first an amorphous material and then a mesomorphic phase, as the moisture sorption increased with exposure to relative humidity. 

Thies R, Kleinebudde P. Melt pelletization of a hygroscopic drug in a high shear mixer. Part 3. Effects of binder variation. Chem Pharm Bull 2001 49(2) 140-146. 

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