Hydroxypropyl methyl cellulose HPMC

Colombo P, Bettini R, Peppas NA. Observation of swelling process and diffusion front position during swelling in hydroxypropyl methyl cellulose (HPMC) matrices containing a soluble drug. J Control Release 1999 61 83-91. 

Miranda and Berglund [79] used a food grade polymer, (hydroxypropyl)methyl cellulose (HPMC), and ammonium sulfate as additives for the recovery of recombinant a-amylase by flotation. The enzyme was removed from the liquid phase by partition to a salted-out HPMC phase and the enzyme-containing polymer floes were recovered by flotation. This system behaved in a manner similar to the flotation of mineral systems. The problem with this technique is the cost of the polymer and the separation of the enzyme from the polymer phase. Both of them complicate the process and increase the separation cost In general, for protein recovery and separation, especially in the pharmaceutical industry, it is not proper to add chemicals to the feed, because they have to be removed from the product completely and this separation causes problems and additive costs. 

Figure 2 The molar mass distributions of two hydroxypropyl-methyl cellulose (HPMC) batches (Metolose 60 SH 10 OOOcps, Shin-Etsu, Tokyo, Japan) determined with SEC connected online to multi-angle scattering (MALS) and refractometric (Rl) detectors. The broad distributions contain HPMC chains ranging from a few thousands up to several millions in molar mass. Despite the fact that the two batches belong to the same viscosity grade, significant differences are seen in the molar mass distributions. This emphasizes the importance of proper characterization of the complete molar mass distribution instead of only estimations via viscosity averages. (Reproduced with permission from Bengt Wittgren, Analytical Development, Astra Hassle/AstraZeneca, Moindal, R D Mbindal.)...

Hydroxypropyl methyl cellulose (HPMC) Chloromethane and propylene oxide... 

The ability of surfactant binding is enhanced through the hydrophobic interaction between polymer hydrophobes and surfactant hydrophobes. Typical model polymers such as hydrophobically ethoxylated urethane (HEUR), ethyl hydroxyethyl cellulose (EHEC), and hydroxypropyl methyl cellulose (HPMC) have been the focus of study. 

Hydroxypropyl methyl cellulose (HPMC) E 464 Cellulose Propylene oxide Soya burgers, sausages, onion rings, potato croquettes, waffles, batters, coatings, doughnuts, gluten free bakery products, shampoo, lotions... 

Sardar, N. and M. Kamil (2012a). Interaction between nonionie polymer hydroxypropyl methyl cellulose (HPMC) and cationic gemini/conventional surfactants. Industrial Engineering Chemistry Research 51(3) 1227-1235. 

When such a diet is not enough, drugs come to the rescue. One type of drug, such as hydroxypropyl methyl-cellulose (HPMC for the stmcture of cellulose, see Section 24-12), binds cholesterol in the stomach and thus prevents it from being absorbed by the body. Ironically, HPMC is used as a thickener in foods, including cheesecake and desserts Another type of drug turns off production of cholesterol directly in the liver and has been used with spectacular success in the last decade. Examples are atorvastatin (Lipitor) and rosuvastatin (Crestor), both top-10 prescription drugs with combined sales of close to 20 billion (see Table 25-1). 

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