3- Hydroxyoctanoic acid

C4 = 3-hydroxybutyric acid, C5 = 3-hydroxyvaleric acid, C6 = 3-hydroxyhexanoic acid, C7 = 3-hydroxyheptanoic acid, C8 = 3-hydroxyoctanoic acid, C9 = 3-hydroxynonanoic acid CIO = 3-hydroxydecanoic acid. 

S,4S)-4,8-Diamino-3-hydroxyoctanoic acid (DAHOA) derivatives were synthesized by the route shown in Scheme II using the known aldehyde Boc-Lys(Z)-CH0 (29) and were converted to the DAHOA peptide analogs shown. Inhibition of penicillopepsin by all statine and DAHOA pepstatin analogs was measured using substrate 21. The results of these determinations are shown in Table I. 

Ethyl-2-methyl-3-hydroxyoctanoic acid, ethyl ester, 37,39,40 4-Ethyl-2-methyl-l,4-octanolide, 37,... 

It is interesting to investigate effects of long side chains on the molecular dynamics and related physical properties of poly(hydroxyalkanoic acid)s. The poly(hydroxyalkanoic acid)s with longer side chains, such as poly(3-hydroxyoctanoic acid) [P(3HO)], have quite different mechanical properties from P(3HB) and P(3HB-co-3HV), being thermal elastmers with low glass transition temperatures ranging from -25 to — 40°C [88] and a much lower crystallinity of about 25-33% [89]. 

Figure 10.1 Chemical structures of (a) poly(3-hydroxybutyric acid), (b) poly(3-hydroxybutyric acid-co-3-hydroxyvaleric acid) and (c) poly(3-hydroxyoctanoic acid).

Experiments using a longer-chain substrate, namely fran.y-2-octenoic acid, revealed that Mucor sp. forms not only the expected 1-octanol (20 %) but also the monooctyl phosphate (21 %) derivative and 3-hydroxyoctanoic acid (50%) as a main product which is generated by another reaction type, namely by water addition to the double bond 63. This latter reaction is reversible. 

PHB-co-PHV [54] is obtained from Azotobacter chroococcum [58, 63). The biodegradation is slower for the copolymers than poly-3-hydroxybutyrate. 3-hydroxy-n-phenylalkanoic acids and 3-hydroxyaliphatic acids are obtained from Pseudomonas putida [59]. Poly (3-hydroxyoctanoic acid) and poly (6-hydroxyhexanoic acid) and poly (3-hydroxyoctanoic acid) [64], Poly-(R)-3-hydroxybutyrate/polyphosphate (PHB/polyP) complexes are isolated from the plasma membranes of bacteria [65,66]. Polyhydroxyoctanoate is produced by feeding octanoic acid to Pseudomonas oleovorans [67]. 

Hydroxyoctanoic acid, H-00363 8-Hydroxyoctanoic acid, H-00364 7-[6-(3-Hydroxy-1 -octenyl)-2,3-... 

Poly(3-hydroxybutanoic acid), a biodegradable polyester, is an insoluble, opaque material that is difficult to process into shapes. In contrast, the copolymer of 3-hydroxy-butanoic acid and 3-hydroxyoctanoic acid is a transparent polymer that shows good solubility in a number of organic solvents. Explain the difference in properties between these two polymers in terms of their structure. 

Poly(3-hydroxybutanoic acid-3-hydroxyoctanoic acid) copolymer... 

Abbreviations PHA polyhydroxyalkanoic acid 3H8 3-hydroxybutyric acid 3HD 3-hydroxydecanoic add 3HDD 3-hydroxydodecanoic acid 3HTD 3-hydroxytetradecanoic acid 3HHx 3-hydroxyhexanoic acid 3HV 3-hydroxyvaleric acid 3HO 3-hydroxyoctanoic acid and 4HV 4-hydroxyvaleric acid... 

Hydroxynonanoic acid, 3-hydroxyundecanoic acid, 5,10-dihydroxydecanoic acid [18,19] 12-Hydroxydodecanoic acid, 12-hydroxy-2-dodecenoic acid, 3-hydroxyoctanoic acid, 13-hydroxytetradecanoic acid, 2-dodecene-1,12-dioic (traumatic) acid, 10- hydroxydodecanoic acid, 12-hydroxydodecanoic acid, 12-hydroxy-2-dodecenoic acid, 11- hydroxyundecanoic acid [16,17,20]... 

Amha 3-amino-2-methyl-hexanoic acid - Dhoaa 2,2,-dimethyl-3-hydroxyoctanoic acid... 

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