2- Hydroxymethylfuran

Bromomethyl-5-methylthiophene gives normal displacement products with amines but it is isomerized on attempted reaction with copper(I) cyanide (Scheme 59) 48MI30200. Whereas 2-hydroxymethylthiophene reacts normally with hydrogen halides to give 2-halomethylthiophenes, reaction of 2-hydroxymethylfuran (2-furfuryl alcohol) with hydrochloric acid results in formation of laevulinic acid (151). 2-Furfuryl alcohol derivatives are... 

Chemical Designations - Synonyms 2-Furancarbinol, Furfuralcohol, alpha-Furylcarbinol, 2-Furylcarbinol, 2-Hydroxymethylfuran Chemical Formula CjHjOj. 

Hydroxymethyl)furan, Triethylamine Jenzen, A. F. et al., J. Fluorine Chem., 1988, 38, 205-208 Reaction of sulfur tetrafluoride with 2-hydroxymethylfuran in presence of triethylamine at —50°C is explosive in absence of a solvent. 

Synonyms AI3-01171 BRN 0106291 CCRIS 2922 EINECS 202 626-1 FEMA No. 2491 2-Furan carbinol 2-Furanmethanol Furfural alcohol Furyl alcohol Furyl carbinol 2-Furyl carbi-nol a-Furyl carbinol 2-Furylmethanol 2-Hydroxymethylfuran NCI-C56224 NSC 8843 UN 2874. 

Hydroxymethylfuran, see Furfuryl alcohol 2-Hydroxymethyloxiran, see Glycidol 4-Hydroxy-4-methylpentanone-2, see Diacetone alcohol 4-Hydroxy-4-methylpentan-2-one, see Diacetone alcohol 4-Hydroxy-4-methyl-2-pentanone, see Diacetone alcohol... 

Aminomethylfurans are converted into 3-hydroxypyridines by acid and an oxidizing agent, e.g. (219) —+ (220). 2-Hydroxymethylfurans with chlorine in aqueous methanol give 3-hydroxy-4-pyrones. 3-Hydroxypyridines can conveniently be prepared by reaction of 2-acylfurans with ammonia (Scheme 75). Pyrrole and dichlorocarbene give some 3-chloropyridine (Section 3.3.1.7.1). 

Reaction of sulfur tetrafluoride with 2-hydroxymethylfuran in presence of triethylamine at —50°C is explosive in absence of a solvent. 

Furan derivatives have been used to inhibit the formation of melanin when combined with other agents <2000JPP2000302642>. For the group consisting of 5-methyl-2(3//)-furanone 86, 2,5-dimethyM-hydroxy-3(2//)-thiophenone, 2-buten -olide, and 2-hydroxymethylfuran 21, the in vitro formation of tyrosinase was inhibited by... 

SYNS 2-FURANCARBINOL 2-FURANMETHANOL FURFURAL ALCOHOL 2-FURFURYLALKOHOL (CZECH) FURYL ALCOHOL a-FURAXCARBINOL 2-FUR iXCARBINOL (2-FL RYL)METHANOL 2-HYDROXYMETHYLFURAN NCI-C56224... 

A furan-derived macrocycle ( calixfuran ), obtained by the condensation of furan with 2-hydroxymethylfuran, has been reported by Musau and Whiting (Figure 14) [25]. Higher oligomers (cyclic pentamer, hexamer and the octamer) were also isolated in small quantities. Functionalized calixfurans are likely to be of interest for further investigations. 

Furanmethano, furan-2-methanol, (2-furyl)methanol, furfuryl alcohol, 2-furylcarbinol, 2-hydroxymethylfuran [98-00-0 FEMA 2491... 

CAS 98-00-0 EINECS/ELINCS 202-626-1 UN 2874 (DOT) FEMA 2491 Synonyms 2-Furancarbinol Furanmethanol 2-Furanmethanol Furfural alcohol Furfuralcohol Furfurol Furyl alcohol 2-Furylcarbinol a-Furylcarbinol (2-Furyl) methanol 2-Hydroxymethylfuran Classification Heterocyclic substituted alcohol Empirical C5H6O2 Formula C4H3OCH2OH... 

F and MF are typical precursors to furan monomers bearing a moiety which can be polymerized by chain-reaction mechanisms. Scheme 6.11 provides a non-exhaustive array of entries into such structures, which have all been synthesized, characterized and polymerized [4], A major exception to this general postulate is constituted by furfuryl alcohol (2-hydroxymethylfuran, FA), which is in fact still today the most important commercially available furan compound, obtained by the catalytic reduction of F involving more than 80 per cent of its world production. FA is widely used as a polycondensation monomer and does not therefore belong to the class of coirpounds shown in Scheme 6.11. 

Chemical Designations — Synonyms 2-Furancarbinol, Furfiiralcohol, alpha-Furylcarbinol, 2-Furylcarbinol, 2-Hydroxymethylfuran Chemical Formula CjHftOj. Observable Characteristics — Physical State (as shipped) Liquid Color Colorless or amber Odor Mildly irritating. Physical and Chemical Properties — Physical State at 15°C and 1 atm. Liquid Molecular Weight 98.1 Boiling Point at 1 atm. 338, 170, 443 Freezing Point 5, -15, 258 Critical Temperature Not pertinent Critical Pressure Not pertinent Specific Gravity 1.13 at 20 C, (liquid) Vapor (Gas) Specific Gravity 3.4 Ratio of Specific Heats of Vapor (Gas) Not... 

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