Hydroxylation and Amination of Carbon-Centered Radicals

Nitro compounds may add to carbon-centered radicals and thus also with the majority of the DNA radicals (Chap. 6.3 only the very strongly reducing radicals such as eaq and C02 reduce the nitro sensitizers to (unstable) hydroxyl-amines McClelland et al. 1984). Originally, the nitro compounds and 02 have just been taken as oxidants irrespective of their mode of action, especially as the efficiency of the sensitizers correlates with their reduction potential (Adams and Cooke 1969 Tallentire et al. 1972 Simic and Powers 1974 Adams et al. 1976a, 1981). This concept is expressed in relationship (88), where C is the sensitizer concentration required to achieve a constant sensitizing response (e.g. an enhancement ratio of 1.6) and E7 the one-electron reduction potential of the sensitizer at pH 7. 

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