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Hydroxyl , oxygen detection

Because of certain misconceptions with regard to the choice of solvent and the occurrence of sulfur-oxygen bond fission in hydroxylic solvents - , it is important to emphasize that one can greatly reduce the rate of this competing process by the use of weak bases. In systems which can undergo facile C—O as well as S—O bond fission, it is possible to control the type of bond cleavage by choosing the appropriate base . A remarkable illustration of this behavior is found in the ethanolysis of sulfinate 6a. In anhydrous ethanol at 90.0° with acetate ion as the added base, 6a yielded ethyl 2, 6-dimethylbenzenesulfinate plus a trace of sulfone 7a. Under the same conditions but with 2,6-lutidine the reaction was slower and sulfone 7a was the only detectable reaction product . ... [Pg.675]

Various hydroxyl and amino derivatives of aromatic compounds are oxidized by peroxidases in the presence of hydrogen peroxide, yielding neutral or cation free radicals. Thus the phenacetin metabolites p-phenetidine (4-ethoxyaniline) and acetaminophen (TV-acetyl-p-aminophenol) were oxidized by LPO or HRP into the 4-ethoxyaniline cation radical and neutral V-acetyl-4-aminophenoxyl radical, respectively [198,199]. In both cases free radicals were detected by using fast-flow ESR spectroscopy. Catechols, Dopa methyl ester (dihydrox-yphenylalanine methyl ester), and 6-hydroxy-Dopa (trihydroxyphenylalanine) were oxidized by LPO mainly to o-semiquinone free radicals [200]. Another catechol derivative adrenaline (epinephrine) was oxidized into adrenochrome in the reaction catalyzed by HRP [201], This reaction can proceed in the absence of hydrogen peroxide and accompanied by oxygen consumption. It was proposed that the oxidation of adrenaline was mediated by superoxide. HRP and LPO catalyzed the oxidation of Trolox C (an analog of a-tocopherol) into phenoxyl radical [202]. The formation of phenoxyl radicals was monitored by ESR spectroscopy, and the rate constants for the reaction of Compounds II with Trolox C were determined (Table 22.1). [Pg.736]


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Hydroxyl detection

Oxygen detection

Oxygen hydroxyl

Oxygenation/hydroxylation

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