Hydroxyapatite hydrogel composite

KHlion, J., et al., 2014a. Fabrication and in vitro biological evaluation of photopolymerisable hydroxyapatite hydrogel composites for bone regeneration. J. Biomater. Appl. 28 (8), 1274-1283. Available at http //www.ncbi.nhn.nih.gov/pubmed/24114559. 

In order to achieve the firm fixation of the artificial cornea to host tissues, composites of collagen-immobilized poly(vinyl alcohol) hydrogel with hydroxyapatite were synthesized by a hydroxyapatite particles kneading method. The preparation method, characterization, and the results of corneal cell adhesion and proliferation on the composite material were studied. PVA-COL-HAp composites were successfully synthesized. A micro-porous structure of the PVA-COL-HAp could be introduced by hydrochloric acid treatment and the porosity could be controlled by the pH of the hydrochloric acid solution, the treatment time, and the crystallinity of the HAp particles. Chick embryonic keratocyto-like cells were well attached and proliferated on the PVA-COL-HAp composites. This material showed potential for keratoprosthesis application. Further study such as a long-term animal study is now required [241]. 

Madhumathl K, Shalumon KT et al (2009) Wet chemical synthesis of chitosan hydrogel-hydroxyapatite composite membranes for tissue engineering applications. Int J Biol Macromol 45 12-15... 

In 2006, Hutchens et al. [112] synthesized a novel composite material consisting of caldum-deficient hydroxyapatite (CdHAP) and microbial cellulose. In the study, CdHAP biomimetically deposited in a microbial cellulose hydrogel produced by Gluconacetobacter hansenii and demonstrated that formation of the composite... 

A collagen/nano-hydroxyapatite/alginate hydrogel system, which has not only high osteoconductive activity but also excellent injectability and sustained release ability, bas been developed by Cao et al. (2012), while Wen and co-workers report on similar composite for the delivery of BMP-2 protein (Wen etal., 2011). 

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