2- Hydroxy-6-methylacetophenone

For oxidation of 2-hydroxy -methylacetophenone, 2-hydroxy-4-chloroacetoph-enone, and 4-bromoacetophenone by Mn4(P207)3, in aqueous HCIO4 using substrates in excess, the kinetic dependence is of zero order in oxidant and first order in H+ and substrates. The mechanism (Scheme 1) of similar oxidation of phenothiazine (PTZ) derivatives by Mn4(P207)3 in the presence of excess of Mn +, P04 , and H2SO4 postulated the formation of final product 5-oxide either from the hydrolysis of PTZ " (step 3) formed in step 2 or from the disproportionation (step 4) of PTZ+ formed in step 1. The kinetics of step 2, studied in acidic phosphate medium, indicated that the rate was H+ ion dependent but independent of PTZ. The kinetics of step 4, studied in acidic sulfate medium, suggested an inverse dependence on PTZ+ and direct dependence on H+ ion. ... [Pg.109]

The stages in the production of salbutamol are as follows the starting material is diacetate , 4 -hydroxy-3 -hydroxymethylacetophenone diacetate which is a waxy powder and a series of reactions produces in turn glycyl compound , 2-(iV-benzyl-A -/ r/-butylamino)-4 -hydroxy-3 -hydroxymethylacetophenone diacetate, then benzyl compound , 2-(iV-benzyl-/er/-butylamine)-4 -hydroxy-3 -hydroxy-methylacetophenone hydrochloride and finally salbutamol, a-/ r/-butyla-minomethyl-4-hydroxy-m-xylene-a,a -dioL... [Pg.176]

Preparation by reaction of concenttated hydrochloric acid with 5-chloro-2-hy-droxy-3-hydroxy-methylacetophenone for 5 days at 20° (95%) [2482],... [Pg.734]

L-Proline also reacts with 2-hydroxy-6-methylacetophenones in boiling DMF to give racemic pyrrolo[2,l-h][l,3]benzoxazines 138 (79JOC4005). For the synthesis of pyrrolo[2,l-c][l,4]benzothiazepines 139, three different syntheses from L-Pro and 2-methylthiobenzoic acid or the disulfide of o-mercaptobenzoyl chloride have been described (88JHC1007). [Pg.59]

C9H10CINO2 5-Chloro-2-hydroxy-4- methylacetophenone oxime ExQ-action-photometric Gravimettic V V 3... [Pg.531]

C9H10CINO2 2-Hydroxy-4-chloro-5- methylacetophenone oxime Exttaction- spectrophotometric Co, Cu, Ni 29... [Pg.531]

Acetic acid has been found to react with toluene to form p-methylace-tophenone (Simons et al., 49), to react with benzene to form acetophenone, and to react with phenol to form p-hydroxy acetophenone. Acetyl chloride also formed acetophenone with benzene and acetic anhydride reacted with toluene to form both p-methylacetophenone and 2,4-diace-tyltoluene. Valeric acid reacted with toluene to form p-tolyl-n-butyl ketone. Both benzoic acid and benzoyl chloride reacted with toluene to form p-tolylphenyl ketone. Acenaphthene with either benzoic acid or benzoyl chloride gave 3-benzoylacenaphthene (Fieser and Hershberg,... [Pg.216]

A pentacyclic diterpene 1 called dictyoxetane contains a most unusual subunit, a 2,7-dioxatricyclo[4.2.1.03>8 ]nonane. During model studies designed to provide access to this key subunit the bicyclic ether 2 was synthesised in the hope that Sn displacement would generate the unsaturated tricyclic oxetane. There was no reaction when 2 was treated with base. Reaction with a catalytic amount of p-toluenesulfonic acid in DMF at 75°C for 24 hours resulted only in formation of 4-methylacetophenone. The hydroxy mesylate 2 is also reported to decompose to 4-methylacetophenone on storage. [Pg.152]

Hexanone, 2-heptanone, 2-octanone, 2-nonanone, 6-methyl-5-hepten-2-one, fenchone, carvone, acetophenone, 2-hydroxy-4,6-dimethoxy-5-methylacetophenone... [Pg.154]

When heated in refluxing toluene for 80 h, IV/87 was converted to 6-chloro-2-hydroxy-4-methylacetophenone [48],... [Pg.65]

Hydroxy-4-methoxyphenyl formate, 790 2-Hydroxy-3-methylacetophenone 2,4-dini-... [Pg.715]

There are two new approaches to the 9-carboxylic acid 613, R = H. One consists in the reaction of dichlorocarbene with 4-methylacetophenone. The initially formed dichloroepoxide reacted with sodium hydroxide, and the main product from the reaction was the hydroxy acid 614, which underwent dehydration to 613 (R = H). The latter formed dimers in boiling water. Methyl (4-methylphenyl)acetate (615) reacted with formaldehyde, and the product 616 was dehydrated to 613 (R = Me). Hydrogenation over rhodium then gave the ester 617, which is also the product of hydroformylation of 615. " ... [Pg.381]

Verghese has published a review about this class. Authentically naturally occurring m-menthanes are m-thymol (687, R = H) and its methyl ether 687 (R = Me), isolated from various Calea species as well as the isobutyl ether 687 (R = iBu) from Athrixia elata. Paknikar has synthesized 687 (R = H) by Grignard reaction of 2-hydroxy-5-methylacetophenone. ... [Pg.391]

The biosynthetic origin of these alkaloids is of some interest. One non-alkaloidal constituent of E. polydactylus is 2-hydroxy-6-methylacetophenone, a structural unit which may be clearly discerned in the alkaloids. This unit is very probably derived from acetate, hence the alkaloids may be formed by the condensation of a polyketomethylene chain with ornithine, as depicted in (19). If so, it would appear that elaeocarpiline and its stereoisomers precede the other alkaloids in the biosynthetic sequence aromatisation and racemisation then constitute the final steps. ... [Pg.81]

H.63) (H.63) Ethanone, l-(2-hydroxy-5-methylphenyl)-, l-(2-hydroxy-5-methylphenyl)-l-ethanone. 2 -hydroxy-5 -methylacetophenone, 2-acetyl-4-methylphenol, o-acetyl-p-cresol, l-hydroxy-2-acetyl-4-methylbenzene [1450-72-2]... [Pg.205]

Furanyl)-3-methyl-2-butenal, F-30038 2 -Hydroxy-4 -methylacetophenone, H-30176 1 -(4-Hydroxyphenyl)-2-propen-1 -ol, H-30241... [Pg.521]

See under W.Methyl.p.phenetidine. p-Methylphenacyl Alccfliol tolyl ketone, p4oluylcarbinol)... [Pg.778]

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