5-Hydroxy-2-mcthyl-4-

Acetyl-5-hydroxy-3-mcthyl-l-phenyl- 527, 627 4-Acetyl-5-hydroxy-3-nitro-l-(4-nitro-phenyl)- 515 4-Acetyl-5-mercapto- 661 3-Acetyl-l -mcthoxycarbonyl-5-methyl- 509 3-Acetyl-l-methyl- 656... 

Arylamino-3-hydroxy-l-methyl- 446 l-Aryl-4-arylazo-5-hydroxy- 437 l-Aryl-4-arylazo-5-hydroxy-3-mcthyl- 531, 642... 

Chlor-allyl)-3,5-dimeLhyl- 426 3(5)-(4-Chlor-benzoyl)-503 4-(2-Chlor-benzoyl)-5-hydroxy-3-mcthyl- 669 Chlorcarbonyl- 654 4-Chlorcarbonyl- 625 l-Chlorcarbonyl-3,5-dimethyl- 647... 

Hydroxy-3-methyl-4-(3-oxo-butanoyl)- 552 5-Hydroxy-3-mcthyl-4-(3-oxo-3-phenyl-propyl)- 666... 

Hydroxy-3-rnethyl-l-(4-pyridyl)- 440 5-Hydroxy-3-mcthyl-l -(4-sulfo-phenyl)- 588... 

Cyano-hydroxy-mcthyl)-l-fluoro-ElOb, 147 (Oxirane + HF/Py)... 

C,5H2 N02 131091-01-5) see Miinacipran hydrochloride 2-hydroxy mcthyl-23-dihydro-l,4-benzodioxin (GjHioO, 3663-82-9) see Guanoxan 2-hydroxymethyl-3,4-dimcthoxypyridinc (CkH, NO, 72830-08-1) see Panloprazolc sodium 2-(hydroxymethyl)-3,5-dimcthyl-4-mcthoxypyridine (C,7H,iN02 86604-78-6) see Omeprazole... 

A combination of substrate-induced and auxiliary-induced stereoselectivity is provided by the diisopinocampheylborinates 11a and lib derived from the chiral ketone (S)-l-benzyloxy-2-mcthyl-3-pentanone52. Whereas this ketone provides no significant diastereoselectivity when converted into the dibutylboron enolate and, subsequently, added to aldehydes, use of the diisopinocampheyl reagents 11a and lib leads to the jS-hydroxy ketones 12 and 13 in a stereoselective manner. The chiral information which is located in the carbon chain of the starting ketone 10 is incorporated into the products ... 

The naphthyl derived ligand, (5)-1-mcthyl-2-[(l-naphthylamino)methyl]pyrrolidine (4) is especially effective in the stereoselective additions of (Z)-l-cthylthio-l-trimethylsilyloxy-l-propene to aldehydes. Thus, quantitative formation of. yyn-adducts is achieved, in addition to high reagent-induced stereoselectivity (>98% ee for the 3-hydroxy thioester products)23 32. 

Metalated SAMP- or RAMP-hydrazones derived from alkyl- or arylethyl ketones 3 add to arylaldehydes both diastereo- and enantioselectively. Substituted / -hydroxy ketones with relative syn configuration of the major diastereomer are obtained with de 51-80% and 70-80% ee. However, recrystallization of the aldol adducts, followed by ozonolysis, furnishes diastereo- and enantiomerically pure (lS, S )-. yn-a-mcthyl-/3-hydroxy ketones 5 in 36-51% overall yield. The absolute configuration of the aldol adducts was established by X-ray crystallographic analysis. Starting from the SAMP- or RAMP-hydrazone either enantiomer, (S,S) or (R,R), is available using this methodology16. 

Heptanal-al + l-Brom-3-mcthyl- 4-Hydroxy-3,3-dimethyl-decen-(I) 83% d.Th. 

Interessante Trimere liefert 2-Mcthyl-propanal. Bei der Beschickung der beiden Elek-trodenraume einer geteilten Zelle (Platin-Elektroden) mit 2-Methyl-propanal/Tetra-butylammonium-hexafluorophosphat entsteht an der Anode 2,4,6-Triisopropyl-1,3,5-trioxan (95% d. Th.) und an der Kathode 4-Hydroxy-5,5-dimethyl-2,6-diisopropyl-l,3-dioxan (90% d. Th.), jeweils in sehr hoher Ausbeute1 ... 

Phenyl-(4-chlor-phenyl)- 542 Phenyl-(4-fluor-phenyI)- 410 PhenyI-[4-(3-hydroxy-butyl)-phenyl]- 296 Phenyl-(2-hydroxymethyI-phcnyl)- 229 Phenyl-(4-hydroxymethyI-phenyl)- 324 PhenyI-(2-hydroxy-phenyl)- 159 Phenyl-(3-methoxy-phenyl)- 410 Phenyl-(4-mcthyl-phenyI)- 410 Phenyl-naphthyl-(l)- 411 Phenyl-[4-(3-oxo-butyl)-phenyl]- 296 Phenyl-pyridyI-(2)- 492 Phenyl-(2,4,6-trimethyI-phenyl)- 411 Triaryl- 561 Trideutero-... 

Dimethyl- -athylester-athylimid 350 2-(Dimethylamino-mcthyl)-3-(2-hydroxy-phenyl)-... 

Methyl- -1,2-dicarbonsaure-anhydrid 176/. (Z)-l-Mcthyl-2-(2-hydroxy-athyl)-1 -methoxycar-bonyl-... 

CN (6a, 1 Ip, 16a, 17a)-6,9-Difluoro-l l-hydroxy-16-mcthyl-3-oxo-17-(l-oxopropoxy)androsta-1,4-diene-17-carbothioic acid -(fluoromethyl) ester... 

C7H22N2 140-80-7) see Chloroquinc Mepacnne 7(77)-amino-3-[[(2,5-dihydro-6-hydroxy-2-methyl-5-oxo-l,2,4-triazin-3-yl)thio]mcthyl]-3-cephem-4-carboxylicadd (C12H13N5O5S2 58909-56-1) see Ceftriaxone (15-franx)-l-amino-2,3-dihydro-l//-inden-2-ol (CyH NO 163061-74-3) see Indinavir sulfiite cis-l-amino-2,3-dihydro-l//-inden-2-ol (C9H11NO 7480-35-5) see Indinavir sulfate... 

Fig. 2 Examples of the structures of a few fast-response electric filed sensitive dyes N-(4-sulpho-butyl)-4-(4-(4-(dipentylamino)phenyl)butadienyl)pyridinium inner salt (RH421, a styrylpyridinium dye), ANNINE 5 (an annellated hemicyanine dye), merocyanine 540, and N-[(4 -dimethylamino)-3-hydroxy-6-flavonyl mcthyl-N,N-trimcthyl ammonium (F4N1, a 3-hydroxychromone dye)...

The enzyme can also catalyze the transfer of an acetyl group from an N-acetylated hydroxylamine (hydroxamic acid) to form an acetoxy product, i.e., an N to O transacetylation and this pathway does not require acetyl Co-A (12). A-hydroxy-4-acetylaminobiphenyl provides an example of this conversion as shown in Figure 7.7. The significance of this pathway is that it leads to the activation of the hydroxamic acid because acetoxy derivatives of aromatic amines are chemically reactive and many are carcinogens such as the heterocyclic amines formed when meat is heated to a high temperature, e.g., 2-amino-1-mcthyl-6-phenylirnidaz()[4,5-i ]pyri(linc. 

Damit im Zusammenhang ist von Intcrcsse, daB bei 2-Hydroxy-5-mcthyl-l,3,4-oxadiazol mit tertiaren Aminen oder Lewissauren als Katalysatoren eine Ringspaltungs-Polymerisation statt-findet710 ... 

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