8-Hydroxy-guanosine

Yin B, Whyatt RM, Perera FP, Randall MC, Cooper TB, Santella RM (1995) Determination of 8-hydroxy-guanosine by an immunoaffinity chromatography-monoclonal antibody-base ELISA. Free Rad Biol Med 18 1023-1032... 

Guanine Purine 2-amino-6-hydroxy Guanosine Guanylicacid... 

Guanine Purine 2-Amino-6-hydroxy Guanosine Guanosine S -phosphate, gua-nylic acid, GMP... 

Devasagayam, T.P.A., Steenken, S., Obendorf, M.S.W., Schultz, W.A. and Sies, H. (1991). Formation of 8-hydroxy(deoxy)guanosine and generation of strand breaks at guanine residues in DNA by singlet oxygen. Biochemistry 30, 6283-6289. 

HA was found to be mutagenic in bacteria, and it was reported that plant chromosomes break in the presence of HA, but it was found to be noncarcinogenic to mice. However, Gross did cite some A-hydroxy compounds (i.e. HA derivatives) as carcinogens . The mechanism of mutagenesis of HA was found to involve primarily interaction with the pyrimidine bases of the cytidine-guanosine pairs. 

Deoxyguanosine A7-(2-Hydroxy-3-buten-l -y l)guanosine (I) Half-lives of spontaneous NMR, MS ... 

Salmon testis A7-(l -Hydroxy-3-buten-2-y l)guanosine (II) depurination of I and II in DNA 50 h HPLC, UV ... 

Calf thymus DNA A7-(l-Hydroxy-3-buten-2-yl)guanosine (II) (pH 7.4). (Neagu etal., 1995) ... 

An important reaction is the deamination of amines by dilute nitrous acid. This reagent, by a complex mechanism, converts the amino groups of cytidine, adenosine, and guanosine to hydroxyl groups hydroxy compounds tautomerize to the corresponding amides (Eq. 5-14). 

Unless a non-radical mechanism accounts for the formation of 4,5-dihydro-5-hydroxy-4-(nitrosooxy)-2 -deoxyguanosine, -N02 must add to the 2 -deoxy-guanosine -OH-adduct via its O-centered mesomeric form in contrast to the nitration of tyrosine, where -N02 reacts as an N-centered radical (van der Vliet et al. 1994 Lymar et al. 1999). 

Biosynthesis of 7,8-didemethyl-8-hydroxy-5-deazaflavin starts from guanosine-5 -triphosphate (GTP), which leads through several steps to 5-amino(6-ribitylamino)-2,4( 1 //,3//)-pyrimidinedione 5 -phosphate, whose addition to 4-hydroxybenzoic acid which comes from shikimate gave the target compound <85JA8300>. The biosynthesis of riboflavin and deazaflavins has been studied in Methanobacterium thermoautotrophicum <91JBC9622>. 

The preparation of 2-hydroxy-3 -pyridinecarboxaldehyde and its 6-acetamido derivative, and their condensation with Fischer s base to give the corresponding spiropyridopyrans have been described. The acetamido spiro compound selectively recognizes guanine, which traps the open colored form by triple hydrogen bond complementarity, thus signaling the presence of guanosine derivatives.79... 

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