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3-Hydroxy-3,4-dihydro-2H-pyrido

Hydroxy-3,4-dihydro-2H-pyrido[2,l-b][l,3]thiazin-5-ium chloride was formed when 2-hydroxy-3-(2-pyridylthio)propyl chloride was stirred in methylene chloride overnight (92JOC6335). When the reaction was carried out in methanolic sodium methylate, 3-(2-oxo-l,2-dihydro-l-pyridyl) thietane was obtained in 58% yield. [Pg.264]

By reacting 2-aminopyridine and epichlorohydrin, Knunjanz187 obtained the hydrochloride of 3-hydroxy-3,4-dihydro-2H-pyrido[l,2-a]pyrimidine (131 R = OH). Analogous products from 4-methyl-, 5-methyl-, 5-halo- and 3,5-dibromo-substituted 2-aminopyridines have been prepared by Soviet workers.188,189 The same products arose from the reaction of 2-aminopyridines and l,3-dichloro-2-propanol.188 189 Klusis and Kuthevicius190 reacted 2-aminopyridine with 3-chloro-1,2-propanediol (127) or 2,3-... [Pg.276]

The hydroxy group of 3-hydroxy-3,4-dihydro-2H-pyrido[l,2- ]pyrimi-dine was acylated with acid chlorides in pyridine and exchanged for chlorine by treatment with thionyl chloride. The resulting chloro derivative (131 mp = 46.5-47 C) was transformed on standing to a compound containing ionic chlorine (mp = 193 C). The structure of the latter remained unclarified. ... [Pg.316]


See also in sourсe #XX -- [ Pg.2 ]




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