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Hydroxy dehydrative glycosylation

Dehydrativeglycosylation of 1-hydroxy donors with Ph2S0/Tf20 in conjunction with thioglycoside acceptors opens the way for sequential double glycosylation, one-pot procedures for trisaccharide synthesis, as exemplified by the efficient one-pot synthesis of the a-Gal epitope and a hyaluronan trisaccharide [566]. This study also shows the potential of selenoglycoside as acceptors in dehydrative glycosylation (Scheme 4.112). [Pg.316]

Seeberger PH, Bilodeau MT, Danishefsky SJ. Synthesis of biologically important oligosaccharides and other glycoconjugates by the glycal assembly method. Aldrichim. Acta. 1997 30 75-92. Gin D. Dehydrative glycosylation with 1-hydroxy donors. J. Carb. Chem. 2002 21 33-52. [Pg.626]

Gin, D, Dehydrative glycosylation with 1-hydroxy donors, J. Carbohydr. Chem., 21, 645-665, 2002. [Pg.190]

The reaction of sugar isothiocyanates with aminosugars described above has also been studied with 1-amino (alkyl and arylamino)-l-deoxy-D-fructose 143 (Scheme 32). Thus, treatment of different 0-acylated sugar isoth-iocyanates with D-fructosamines 143 gave M-glycosyl-5-hydroxy-5-tetritolyl-imidazolidine-2-thiones 144 as pairs of diastereomers in almost quantitative yield [ 152]. The reaction times were shorter (15-20 min) for fructosamine or its M-methyl derivatives than in the cases of N-aryl derivatives (8-24 h). Acid-catalyzed dehydration of 144 with ethanolic TFA at rt led to 147 in 65-77% yield. These compounds can be considered simultaneously as M-nucleosides and acyclic C-nucleosides of imidazoline-2-thiones. [Pg.91]

Example an heteropoly acid act both as promoter and dehydrating agent in the glycosylation of an anomeric hydroxy sugar donor... [Pg.199]


See other pages where Hydroxy dehydrative glycosylation is mentioned: [Pg.84]    [Pg.33]    [Pg.37]    [Pg.38]    [Pg.38]    [Pg.49]    [Pg.204]    [Pg.214]    [Pg.216]    [Pg.210]    [Pg.22]    [Pg.465]    [Pg.47]    [Pg.34]    [Pg.35]    [Pg.35]    [Pg.41]    [Pg.45]    [Pg.45]    [Pg.51]    [Pg.687]    [Pg.212]    [Pg.33]    [Pg.737]    [Pg.213]    [Pg.215]    [Pg.225]   
See also in sourсe #XX -- [ Pg.212 ]




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Dehydrative glycosylation

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