Hydroxy acids cleavage

Glycol and o -hydroxy acid cleavage Oxidative decarboxylation Oxidative rearrangement of olefins... 

Pyridazine N-ethoxycarbonylimide photolysis, 3, 13 Pyridazine, 4-gJycosyloxy-rearrangement, 3, 15 Pyridazine, halo-applications, 3, 56 Pyridazine, hexahydro-, 3, 40 photoelectron spectra, 2, 20-21 Pyridazine, hydrazino-reductive cleavage, 3, 34 synthesis, 3, 35 Pyridazine, hydroxy-acidity, 3, 4 Pyridazine, 3-hydroxyl-oxide... 

Optically pure D- and L-glyceric adds were made by cleavage of vicinal diols or of a-hydroxy acids by RuCyaq. Na(C10) pH 8 (Fig. 4.6) [398], The system RuCyaq. Na(IOyCH3CN-CCl oxidised PhCMeCH(0H)CH20H to PhCMeCOOH [260], and RuCyaq. Na(ClO)/0°C converted 1,2-dihydroxycyclohexane to adipic add [35,256]. 

Cleavage of esters 6 (p 407) to give hydroxy acids 7 of known configuration96. 

Cyclization of hydroxy acids 0-24 Cyclization of halo acids 0-89 Intramolecular coupling 2-43 Cleavage of cyclic a-cyano ketones 5-4 Internal addition of alcohols to a ke-tene function... 

N-Methylated y-amino-p-hydroxy acids are accessible by the usual synthetic sequences, i.e. aldol condensation or y-amino-P-oxo ester reduction, starting from the corresponding N-methylated a-amino acids, but are obtained with low diastereoselectivity. 61-63 Alternatively, Brown allylboration of the ALBoc-ALMe amino aldehyde 16 (R1 = Bzl, X=Boc, Y = Me) gives the allyhc N-methylated intermediate 27 in 64% yield and 90% de (Scheme 12). 64 Oxidative cleavage of the alkenol is performed using the two-step ozonolysis and sodium chlorite oxidation sequence. 

Morpholine-2,5-diones have been prepared by intramolecular, nucleophilic cleavage of polystyrene-bound amino acids acylated with a-hydroxy acids (Entry 2, Table... 

---