Hydrotalcite antacids

Lambrecht, N., Korolkiewicz, R and Peskar, B.M. (1992). Effects of endo nous nitric oxide (NO) inhibition on the gas-troprotective activity of the antacid hydrotalcit in rats. Gas-troenterolcgy 102, A105. 

Initially, Byk Gulden s anti-ulcer investigations concentrated on the development of antacids. In 1957 [14,15], Byk Gulden invented the antacid magaldrate (Rio-pan ). This compound consists of a hydrotalcite-like layered structure, which shows a rapid partial neutralization of the acid to pH 4.0-4.5 and a strong addi-... 

Vatier J, Ramdani A, Vitre MT, Mignon M. Antacid activity of calcium carbonate and hydrotalcite tablets. Comparison between in vitro evaluation using the artificial stomach-duodenum model and in vivo pH-metry in healthy volunteers. Arzneimittelforschung 1994 44(4) 514-18. 

Magnesium carbonate hydroxide Magnesium peroxide Sodium bicarbonate antacid active Hydrotalcite... 

Nanoclays can be categorized into cationic and anionic types. Cationic nanoclays are based on smectite clays. An example is montmorillonite (MMT), a hydrated Al, Mg silicate that may contain cations such as Na+ and Ca++ between the anionic layers. In contrast, anionic clays contain cationic layers and anions such as Cr and in the interlayer space. Typical examples include layered double hydroxides (LDH) and hydrotalcite (HT), a mostly synthetic hydrated magnesium and aluminum carbonate salt. Whereas MMT is commonly used as a nanofiller to improve thermal, mechanical, and barrier properties, LDHs have many attractive properties that lead to application as surfactant adsorbents, biohybrid materials, antacid food formulations, acid neutralizers, and active pharmaceutical ingredients excipients [37, 13, 28, 14, 35]. 

Stead et al. [11] that deactivation on inorganic salts like aluminum hydroxide may simply concern adsorption of the antifoam onto the salt, rendering both materials less available. By contrast, tablets based on hydrotalcite as antacid showed stable antifoam and antacid behavior even after storage for 1.8 years at 37°C. If adsorption of simethicone onto the antacid is the cause of deactivation, then it is not, however, obvious why it should not occur on a carbonate clay like hydrotalcite. 

---