Hydrophobically assisted switching

SPOS also benefited from other technical improvements such as the on-resin analytical methods [112], the capture-release purification technique [113], and hydrophobically assisted switching phase [114], Recently, chiral auxiliary-mediated 1,2-n.v-glycosylations were introduced to SPOS, allowing for the efficient and stereoselective assembly of oligosaccharides [115] (see Chapter 7). 

Rademann and co-workers have applied the hydrophobically assisted switching phase (HASP) synthesis for a glycolipid library [145]. The HASP method is further explained in Chap. 5.5. They used the method for the synthesis of immunostimulative rhamnolipids to observe proin-flammatory activities in human mononuclear cells. 

J. Bauer and J. Rademann, Hydrophobically assisted switching phase synthesis The flexible combination of solid-phase and solution-phase reactions employed for oligosaccharide preparation, J. Am. Chem. Soc., Ill (2005) 7296-7297. 

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